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TranscriptomicsTranscription profiling of mouse wild type, Fah and Fah, p21 ON and OFF NTBC animals
Fumarylacetoacetate hydrolase (Fah), the last enzyme of the tyrosine degradation pathway, is specifically expressed in hepatocytes in the liver. Loss of Fah leads to liver failure in mice within 6-8 weeks. This can be prevented by blocking tyrosine degradation upstream of Fah with 2-(2-nitro-4-trifl...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-11098 | biostudies-arrayexpress
TranscriptomicsIn vivo hepatic reprogramming of myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosis
We developed in vivo reprogramming of myofibroblasts (MFs) into induced hepatocytes (MF-iHeps) using adeno-associated virus serotype 6 (AAV6) vectors expressing hepatic transcription factors in MF fate tracing (Lrat-Cre;R26R-ZsGreen) mice with carbon tetrachloride (CCl4)-induced liver fibrosis. To d...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-81491 | biostudies-arrayexpress
TranscriptomicsGene expression data of hepatocytes derived from human fibroblasts, human iPSCs, and human adult hepatocytes
Generation of human fibroblast-derived hepatocytes capable of extensive proliferation, as evidenced by significant liver repopulation of mice. Unlike current protocols for deriving hepatocytes from human fibroblasts, ours did not generate iPSCs, but shortcut reprogramming to pluripotency to generate...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-52309 | biostudies-arrayexpress
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