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TranscriptomicsChanges in gene expression in BAZ1B knockout and heterozygous targeted clones
Williams syndrome transcription factor (WSTF) is a multifaceted protein that is involved in several nuclear processes, including replication, transcription, and the DNA damage response. WSTF participates in a chromatin-remodeling complex with the ISWI ATPase, SNF2H, and is thought to contribute to t...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-47390 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Hodgkin Lymphoma cell line following REL-B depletion
The expression array data will be merged with Rel-B ChIP-Seq data in HL cell lines. This will show REL-B direct and indirect controlled downstream target genes HL cells were infected with a retrovirus that delivers a specific shRNA sequence to knock down the expression of REL-B
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-35224 | biostudies-arrayexpress
TranscriptomicsmiRNA profiles of brain glioma stem cells and normal neural stem cells
A human microarray comprising 1658 human genome probes was used to evaluate the specific expression of miRNA between brian glioma stem cells (GSC) and normal neural stem cells(NSC). 2 total RNA samples are analyzed, brian glioma stem cells (GSC) and normal neural stem cells(NSC). cell type: brain g...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-41032 | biostudies-arrayexpress
GenomicsDynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [ChIP-Seq]
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using deep sequencing RNA-seq and ChIP-seq methods to track genome-wide shifts in transcripti...
ORGANISM(S): Mus musculus 
2012-04-13 | E-GEOD-31233 | biostudies-arrayexpress
MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
TranscriptomicsDynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [RNA-Seq]
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using deep sequencing RNA-seq and ChIP-seq methods to track genome-wide shifts in transcripti...
ORGANISM(S): Mus musculus 
2012-04-13 | E-GEOD-31234 | biostudies-arrayexpress
GenomicsH2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics [ChIP-seq]
While it has been clearly established that well positioned H2A.Z-containing nucleosomes flank the nucleosome depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here th...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41371 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Analysis of Somatic Copy Number Alterations and Gene Expression in Metastatic Melanoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-04-07 | E-GEOD-23056 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila developmental time series
Michelle N. Arbeitman, Eileen E. M. Furlong, Farhad Imam, Eric Johnson, Brian H. Null, Bruce S. Baker, Mark A. Krasnow, Matthew P. Scott, Ronald W. Davis and Kevin P. White. Gene Expression During the Life Cycle of Drosophila melanogaster, Science, 297: 2270-2275, 2002. This work can be accessed fro...
ORGANISM(S): Drosophila melanogaster 
2004-11-06 | E-FLYC-6 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Analysis of Somatic Copy Number Alterations (CGH, SNP) and Gene Expression (RNA-seq) in Metastatic Melanoma
All cancers are diseases of the genome. A combination of somatic point mutations, focal amplifications and deletions, and chromosome level aberrations conspire to disrupt gene expression and the interplay between signaling pathways that control normal growth and tissue homeostasis. Here we investiga...
ORGANISM(S): Homo sapiens 
2011-04-07 | E-GEOD-22928 | biostudies-arrayexpress
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