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UnknownRe-evaluating the Cu K pre-edge XAS transition in complexes with covalent metal-ligand interactions.
Not available
S-EPMC5647745 | biostudies-literature
UnknownMetal binding studies and EPR spectroscopy of the manganese transport regulator MntR.
Not available
S-EPMC2561245 | biostudies-literature
UnknownA new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A.
Not available
S-EPMC2516375 | biostudies-literature
UnknownCommutability assessment of new standard reference materials (SRMs) for determining serum total 25-hydroxyvitamin D using ligand binding and liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays.
Not available
S-EPMC12003064 | biostudies-literature
UnknownWhole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Not available
S-EPMC12418676 | biostudies-literature
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS)
LIN28 is a conserved RNA binding protein implicated in pluripotency, reprogramming and oncogenesis. Previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) targets. Through cross-linking...
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39872 | biostudies-arrayexpress
UnknownTmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Not available
S-EPMC9579145 | biostudies-literature
TranscriptomicsThe histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (expression data)
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing di...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-36347 | biostudies-arrayexpress
GenomicsLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (MeDIP-seq)
DNA methylation is tightly regulated throughout mammalian development and altered methylation patterns are a hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in acute myeloid leukemia (AML) and has been suggested to protect CpG islands and promoters from aberrant methyla...
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-59579 | biostudies-arrayexpress
UnknownRobust and stable transcriptional repression in Giardia using CRISPRi.
Not available
S-EPMC6337905 | biostudies-literature
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