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TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
Transcriptomics7q11.23 dosage-dependent dysregulation in the human pluripotent state primes aberrant transcriptional programs in disease-relevant lineages (microarray)
We apply the cellular reprogramming experimental paradigm to two disorders caused by symmetrical copy number variations (CNV) of 7q11.23 and displaying a striking combination of shared as well as symmetrically opposite phenotypes: Williams Beuren syndrome (WBS) and 7q microduplication syndrome (7dup...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63040 | biostudies-arrayexpress
TranscriptomicsCoordination in the transcriptome and proteome of the diatom Thalassiosira pseudonana reveals a diverse phosphorus stress response
Phosphorus (P) is a critical driver of phytoplankton growth and ecosystem structure and function in the ocean. Diatoms are an abundant and widespread functional group of phytoplankton that are responsible for significant amounts of primary production in the ocean, however there has not been a compre...
ORGANISM(S): Thalassiosira pseudonana CCMP1335 
2013-08-03 | E-GEOD-28134 | biostudies-arrayexpress
TranscriptomicsEffect of 17 M-NM-2-estradiol on developing zebrafish embryos
Estrogen signaling is important for vertebrate embryonic development. Here we have used zebrafish (Danio rerio) as a vertebrate model to identify estrogen regulated genes during the first 4 days of development. Zebrafish embryos were exposed to 1 M-BM-5M 17M-NM-2-estradiol from 3 hours post fertiliz...
ORGANISM(S): Danio rerio 
2013-12-31 | E-GEOD-42766 | biostudies-arrayexpress
TranscriptomicsWhole Transcriptome RNA Sequencing Detects Multiple 1a,25-Dihydroxyvitamin D3-Sensitive Metabolic Pathways in Zebrafish Embryos
Vitamin D receptors (VDR) are abundantly expressed in developing zebrafish as early as 48 hours post-fertilization, and prior to the development of a mineralized skeleton, and mature intestine and kidney. We probed the role of VDR in zebrafish biology by examining changes in expression of RNA by wh...
ORGANISM(S): Danio rerio 
2012-06-28 | E-GEOD-38575 | biostudies-arrayexpress
TranscriptomicsRegulation of endometrial bleeding by uNK cells
Uterine NK cells (uNK) play a role in the regulation of placentation but their functions in non-pregnant endometrium are not understood. We have previously reported suppression of endometrial bleeding and alteration of spiral artery morphology in women exposed to asoprisnil, a progesterone receptor...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-47577 | biostudies-arrayexpress
TranscriptomicsLignocellulose-induced regulation of Phanaerochaete chrysosporium genes
Transcript profiles of Phanerochaete chrysosporium grown on ball-milled aspen or ball-milled pine were analyzed. Array design based on the DoE's Joint Genome Institute's v2.1 annotation. Goal is to define genes involved in lignocellulose degradation. From a data set of 10,004 unique alleles, each Ro...
ORGANISM(S): Phanerochaete chrysosporium 
2011-06-02 | E-GEOD-27941 | biostudies-arrayexpress
UnknownA randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure.
Not available
S-EPMC6413330 | biostudies-literature
TranscriptomicsM. sedula transcriptional response to ferrous iron and RISC supplements
Abstract: The crenarchaeal order Sulfolobales collectively contains at least five major terminal oxidase complexes. Based on genome sequence information, all five complexes are found only in Metallosphaera sedula and Sulfolobus tokodaii, the two sequenced Sulfolobales capable of iron oxidization. Wh...
ORGANISM(S): Metallosphaera sedula 
2008-10-22 | E-GEOD-12044 | biostudies-arrayexpress
TranscriptomicsMismatch oligonucleotides in human and yeast
Background Mismatched oligonucleotides are widely used on microarrays to differentiate specific from nonspecific hybridization. While many experiments rely on such oligos, the hybridization behavior of various degrees of mismatch (MM) structure has not been extensively studied. Here, we present the ...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-13175 | biostudies-arrayexpress
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