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TranscriptomicsSF-1 and RNF31 knockdown and forskolin treatment
The human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 with luciferase-targeting siRNA as control. Combined with forskolin treatment.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MEXP-3259 | biostudies-arrayexpress
MetabolomicsIntegration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance
The development of reliable, mixed-culture biotechnological processes hinges on understanding how microbial ecosystems respond to disturbances. Here we reveal extensive phenotypic plasticity and niche complementarity in oleaginous microbial populations from a biological wastewater treatment plant. W...
2021-04-06 | MTBLS2021 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis Col-0 plants with wild type, arr1-1 knock-out, ARR1 over-expressor and ARR1-SRDX fusion protein over-expressor genotypes treated with 6-Benzyladenine for different lengths of time
Arabidopsis thaliana Col-0 plants and three other genotypes (ARR1 overexpressor, arr1-1 knockout, overexpressor of ARR1-SRDX fusion protein) were grown in liquid media (1/2 MS, 1 g/L sucrose, 0.5 g/L MES, pH 5.7) in a Percival AR-66L growth chamber at 24 oC, 16:8 h day:night cycle, and 100 µE light ...
ORGANISM(S): Arabidopsis thaliana 
2008-08-31 | E-MEXP-689 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of kidney samples from Wilms tumor patients to accurately map 1p13 breakpoints
Wilms tumour karyotypes frequently exhibit recurrent, large-scale chromosomal imbalances, among the most common of which are concurrent loss of 1p and gain of 1q. We have previously identified a novel breakpoint at 1p13 by 1Mb-spaced array CGH, and undertook a fine-tiling oligonucleotide array appro...
ORGANISM(S): Homo sapiens 
2007-03-21 | E-TABM-155 | biostudies-arrayexpress
MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis Col-0 wild-type and 35S:ARR1-SRDX transgenic seedlings either induced with 6-Benzyladenine or mock-treated
6 days old Arabidopsis thaliana of Col-0 wild-type and 35S:ARR1-SRDX transgenic seedlings grown in liquid culture (1/2 MS, 1 g/L sucrose, 0.5 g/L MES, pH 5.7) were induced with either 5 µM 6-Benzyladenine (a cytokinin analog) for 15 or 120 min, or mock-treated 120 min as a control. These samples wer...
ORGANISM(S): Arabidopsis thaliana 
2008-07-03 | E-ATMX-11 | biostudies-arrayexpress
ProteomicsHadBD dehydratase from Mycobacterium tuberculosis FAS-II: a singular structure for a unique function
Mycolic acids (MAs) are a unique class of lipids that are essential for viability, virulence and persistence of Mycobacterium tuberculosis (Mtb). Therefore, enzymes involved in MAs biosynthesis represent important class of drug targets. We previously showed that (3R)-hydroxyacyl-ACP dehydratase (HAD...
ORGANISM(S): Mycobacterium bovis BCG str. Pasteur 1173P2 
2024-03-21 | PXD043977 | Pride
(3r)-hydroxyacyl-acp dehydratase Structure-function relationships. Mycolic acids Hydratase 2 Mycobacterium tuberculosis Hotdog fold Crystal structure Catalytic subunit Substrate specificity Fatty acid synthase type ii system 
TranscriptomicsMicroRNA profiling of the NCI-60 panel of human cancer cell lines
Advances in the understanding of cancer cell biology and response to drug treatment have benefited from new molecular technologies and methods for integrating information from multiple sources. The NCI-60, a panel of 60 diverse human cancer cell lines, has been used by the National Cancer Institute...
ORGANISM(S): Homo sapiens 
2007-04-02 | E-MEXP-1029 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast cell cycle, cdc25 elutriation + block and release
Cell cycle timecourse of fission yeast using both selective (elutriation) and whole-culture (temperature-sensitive mutant cdc25) synchronisation methods
ORGANISM(S): Schizosaccharomyces pombe 
2004-04-01 | E-MEXP-59 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast cell cycle, cdc25 sep1 block and release
Cell cycle timecourse of fission yeast using a whole-culture (temperature sensitive mutant cdc25) synchronisation method in a sep1 deletion background
ORGANISM(S): Schizosaccharomyces pombe 
2004-04-01 | E-MEXP-61 | biostudies-arrayexpress
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