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TranscriptomicsRNA-seq profiling of Medulloblastoma
An observational experiment to RNA-seq profile 331 primary tumours from patients diagnosed with Medulloblastoma.
ORGANISM(S): Homo sapiens 
2022-09-01 | E-MTAB-10767 | biostudies-arrayexpress
ProteomicsLoss of POGLUT2 and 3 eliminates O-glucose at predicted sites but does not alter other modifications on EGFs
Fibrillins play a critical role in tissue/organ development and cardiopulmonary function. Here we showed that O-glucosylation of the fibrillins’ epidermal growth factor-like repeats by protein O-glucosyltransferase 2 (POGLUT2) and POGLUT3 was indispensable for in vivo function of mouse fibrillins. L...
ORGANISM(S): Mus Musculus 
2024-06-10 | PXD043827 | panorama
TranscriptomicsMethylation profiling of Malignant Rhabdoid Tumours
An observational experiment to methylation profile 79 SMARCB1 negative primary tumours from patients diagnosed with Malignant Rhabdoid Tumours.
ORGANISM(S): Homo sapiens 
2020-07-15 | E-MTAB-6708 | biostudies-arrayexpress
TranscriptomicsExpression profiling following SMARCB1 re-expression in MRT cell lines time course over 14 days
MRT cell lines KD, SWOH, LM, DEV and G401 were expression profiled following SMARCB1 re-expression using a lentivirus. Samples were taken at Day 0,1,3,7 and 14 and compared to empty vector control experiments.
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-6674 | biostudies-arrayexpress
TranscriptomicsCombined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease [gene expression]
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive d...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62625 | biostudies-arrayexpress
ProteomicsPOGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of FBN1
Fibrillin-1 (FBN1) is the major component of extracellular matrix microfibrils, which are required for proper development of elastic tissues including heart and lung. Through protein-protein interactions with latent TGF-beta binding protein 1 (LTBP1), microfibrils assist regulation of TGF-beta signa...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD025725 | Pride
Extracellular matrix protein Egf repeats Mass spectrometry Glycosylation Protein secretion Protein folding 
ProteomicsPoglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues
Fibrillins, which are extensively O-glucosylated by POGLUT2 and 3, are crucial for development and cardiopulmonary function. Using primary dermal fibroblasts derived from our POGLUT 2 and 3 double knockout mouse model combined with proteomics analyses, we show that loss of O-glucose modifications on...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-10 | PXD043730 | Pride
Mouse Q exactive Dermal fibroblasts Secretome Extracellular matrix 
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human breast cancer cell lines MCF7 and T74D naive and resistant to palbociclib treated with capivasertib, fulvestrant and combination
T47D and MCF7 cell lines were treated with long-term (continuous) palbociclib to induce 4 resistant cell-lines (T47D RB-, T47D CDK6H, MCF7 RB- and MCF7 PacqR). Each cell line (both parental and resistant) were then treated with DMSO (control), capivasertib monotherapy, fulvestrant monotherapy and ca...
ORGANISM(S): Homo sapiens 
2023-08-14 | E-MTAB-13262 | biostudies-arrayexpress
GenomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [ChIP-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60130 | biostudies-arrayexpress
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