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TranscriptomicsMuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.
MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy Four strain-matched groups of 3-8 week old mice were investigated: 1) MuRF1 -/- Fenofibrate feed; 2) MuRF1 -/- chow feed; 3) MuRF1 +/+ Fenofibrate feed; 4) MuRF1 +/+ chow feed at...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-68480 | biostudies-arrayexpress
TranscriptomicsCardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo
Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypica...
ORGANISM(S): Mus musculus 
2009-06-03 | E-GEOD-11661 | biostudies-arrayexpress
ProteomicsCardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover
The association between reduced myofilament force-generating capacity (Fmax) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show impaired Fmax arises from reduced BAG3-mediated sarcomere turnover. Myofilament BAG3 expression decreases in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-11-06 | MSV000086422 | MassIVE
UnknownProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
Not available
S-EPMC5920066 | biostudies-literature
UnknownIntraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study.
Not available
S-EPMC10364732 | biostudies-literature
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