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Interactions between metabolites and proteins play an integral role in all cellular functions. Here we describe an affinity-purification (AP) approach in combination with LC/MS-based metabolomics and proteomics that allows, to our knowledge for the first time, to analyse protein‒metabolite and prote...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-10-09 | PXD006294 | Pride
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
Arabidopsis plants grown in vitro on control media on a nylon mesh; transfered after 7days either to control or 0.2mM 3-Methoxybenzamide (3MB) containing media were sampled after 24, 48, 96 and 168h to obtain data if/how PARP inhibition changes transcription of plants in respect to the observed grow...
ORGANISM(S): Arabidopsis thaliana 
High-density kinetic analysis of the metabolomic and transcriptomic response of Arabidopsis to temperature and light
ORGANISM(S): Arabidopsis thaliana 
Arabidopsis plants were grown in 6 laboratories, and RNA was labeled and hybridized to AGRONOMICS1 arrays.
ORGANISM(S): Arabidopsis thaliana 
Systems analysis reveals that Chlamydomonas reinhardtii responds rapidly and flexibly to an increase in light intensity. Rising metabolite levels and post-translation regulation facilitate a rapid increase in the rate of carbon fixation and a slightly delayed increase in the rate of growth, and slow...
ORGANISM(S): Chlamydomonas reinhardtii 
Reduction in expression of the INDY gene in Drosophila melanogaster and Caenorhabditis elegans prolongs life span, and in D. melanogaster augments mitochondrial biogenesis in a manner akin to caloric restriction. However, the cellular mechanism by which INDY does this is unknown. In order to examine...
ORGANISM(S): Mus musculus 
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