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TranscriptomicsSingle Cell Analysis of B cells in COVID-19 comprising active and recovered disease
Using COVID-19 as model, we set out to identify serological, cellular and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-11011 | biostudies-arrayexpress
TranscriptomicsSingle Cell data of B cells from patients with chronic Hepatitis C and sustained viral response
We dissect HCV imprinting of B cell repertoires in patients with chronic disease. The persistent character of the oncogenic B cell repertoire generated by HCV may point to a chronically elevated lymphoma risk in these patients even years after HCV cure.
ORGANISM(S): Homo sapiens 
2023-11-30 | E-MTAB-12502 | biostudies-arrayexpress
GenomicsIGHV immune receptor sequencing data from patients with chronic Hepatitis C infection and sustained viral response to hepatitis C
We dissect HCV imprinting of B cell repertoires in patients with chronic disease. The persistent character of the oncogenic B cell repertoire generated by HCV may point to a chronically elevated lymphoma risk in these patients even years after HCV cure.
ORGANISM(S): Homo sapiens 
2023-12-14 | E-MTAB-12585 | biostudies-arrayexpress
TranscriptomicsA20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors
Genetic TNFAIP3 (A20) inactivation is a classical somatic lymphoma lesion and the genomic trait in haploinsufficiency of A20 (HA20). Single-cell sequencing reveals “pre-lymphoma” transcription signatures in lymphocytes of HA20 patients.
ORGANISM(S): Homo sapiens 
2023-07-12 | E-MTAB-12485 | biostudies-arrayexpress
GenomicsIGHV and TRB immune repertoire sequencing data from A20 haploinsufficiency and healthy humans.
Genetic TNFAIP3 (A20) inactivation is a classical somatic lymphoma lesion and the genomic trait in haploinsufficiency of A20 (HA20). In a cohort of 33 HA20 patients, we show that heterozygous TNFAIP3 loss skews immune repertoires towards lymphocytes with classical self-reactive antigen receptors typ...
ORGANISM(S): Homo sapiens 
2023-07-28 | E-MTAB-12491 | biostudies-arrayexpress
TranscriptomicsExpression data from primary Glioblastoma in adults
Gene expression profiling revealed over-representation of a distinct (proneural-like) expression signature in long-term survivors that was linked to IDH1/2 mutation. However, among the IDH1/2-wildtype patients, tumors from long-term survivors did not show distinct gene expression profiles and includ...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-53733 | biostudies-arrayexpress
TranscriptomicsGene x environment effect of serotonin transporter genotype and acute stressor on amygdala gene expression
The amygdala is a prominent region of the brain processing stress-related emotion and vigilance. Additionally it is known that the serotonergic system is strongly involved in stress response and adaptation. The serotonin transporter (5-HTT) as key regulator of serotonergic activity in the brain is a...
ORGANISM(S): Mus musculus 
2013-03-13 | E-GEOD-40393 | biostudies-arrayexpress
TranscriptomicsExpression data from cerebral tumors of WHO grade II and III
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor s...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-61374 | biostudies-arrayexpress
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