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TranscriptomicsGene expression data from Wilms tumor samples
Wilms tumor (nephroblastoma) is a pediatric kidney tumor that arises from renal progenitor cells. Since the blastemal type is associated with adverse prognosis, we characterized such Wilms tumors by exome and transcriptome analysis. We detected novel, recurrent somatic mutations affecting the SIX1/2...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-53224 | biostudies-arrayexpress
TranscriptomicsClassification of a frameshift/extended and a stop mutation in WT1 as gain of function mutations which activate cell cycle genes and promote Wilms tumor cell proliferation
The Wilms tumor 1 (WT1) gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumor development and an oncogene for diverse malignant tumors. We recently established cell lines from primary Wilms tumors and identified the corresponding...
ORGANISM(S): Homo sapiens 
2014-05-12 | E-GEOD-54635 | biostudies-arrayexpress
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