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TranscriptomicsGenome-wide profiling of 2 month vs >6 month old muscle Treg cells
We report age-related gene expression of Treg cells isolated from injured muscle and spleen. Male C57BL/6 Foxp3-GFP reporter mice were injured intramuscularly with cardiotoxin. Tregs were sorted directly into Trizol from injured muscle and spleen 4 days post-injury. Gene expression profiling of musc...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-76733 | biostudies-arrayexpress
TranscriptomicsRole of NFBD1 in global gene expression
NFBD1 (nuclear factor with BRCT domains 1), also known as MDC1 (mediator of DNA damage signaling 1), is a protein involved in the ATM signaling pathway in response to DNA damage. In addition to a role in signaling, NFBD1 possesses transactivation activity, suggesting that it may influence transcrip...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-23010 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mesangial cell line MES-13 to examine the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptome.
The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosami...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2557 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis microgametogenesis
Aims We aim to use transcriptome analysis to establish on a genome-wide scale the identity and regulatory clusters of genes that specify microgametogenesis from the haploid microspore to mature functional pollen in Arabidopsis. Background Pollen as the haploid male gametophyte plays a vital role in ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mesangial cells treated with transforming growth factor b1
TGF-beta1 is a pleiotropic cytokine that regulates multiple cellular functions including cell proliferation, differentiation, and apoptosis. It has been identified as one of the mediators of renal hypertrophy and accumulation of extracellular matrix proteins in the diabetic glomerular mesangium. Pre...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2558 | biostudies-arrayexpress
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
TranscriptomicsHOX genes: potential candidates furthering the development of larynx squamous cell carcinoma.
Larynx squamous cell carcinoma (LSCC) is the second most aggressive cancer from head and neck (HSCC). Survival of LSCC patients has been found worsening, albeit significant advances in technology and therapeutics were made. We sought to clarify new genetic targets driven the development of LSCC. Ana...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-59102 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Arabidopsis spl7 identifies two genes required for copper acquisition and a copper dependence of iron homeostasis
The transition metal copper (Cu) is an essential element for all living organisms. In plants, Cu plays key roles in electron transport chains of chloroplasts and mitochondria, as well as in cell wall metabolism, ethylene perception, molybdenum cofactor synthesis and oxidative stress protection. Beca...
ORGANISM(S): Arabidopsis thaliana 
2013-10-14 | E-GEOD-24696 | biostudies-arrayexpress
UnknownImpact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study.
Not available
S-EPMC12451838 | biostudies-literature
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