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UnknownPhysiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study.
Not available
S-EPMC3871511 | biostudies-literature
TranscriptomicsTranscriptome Remodeling Associated with Chronological Aging in the Dinoflagellate, Karenia brevis
To gain an understanding of processes that underlie chronological aging in this dinoflagellate, a microarray study was carried out to identify changes in the global transcriptome that accompany the entry and maintenance of stationary phase up to the onset of cell death. The transcriptome of K. brevi...
ORGANISM(S): Karenia brevis 
2012-01-01 | E-GEOD-31913 | biostudies-arrayexpress
TranscriptomicsThe transcriptional program controlled by Runx1 during early hematopoietic development
This SuperSeries is composed of the following subset Series: GSE29112: The transcriptional program controlled by Runx1 during early hematopoietic development (expression data) GSE29514: The transcriptional program controlled by Runx1 during early hematopoietic development (ChIP-seq data) Refer to in...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-29515 | biostudies-arrayexpress
UnknownPlinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling.
Not available
S-EPMC6439430 | biostudies-literature
TranscriptomicsGene expression profiles of the diabetic glomerular endothelial cell
The objective of this study is to create an encyclopedia of all genes expressed in the glomerular endothelial cell under normal and diabetic conditions. We utilized Tie2-GFP transgenic mice to mark cells of the glomerular endothelium. To induce diabetic nephropathy (DB), a genetic model of DB, BKS...
ORGANISM(S): Mus musculus 
2010-08-16 | E-GEOD-21324 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of diabetic kidney cortices obtained from ICAM-1 deficient mice and wild type mice.
In the present study, we aimed to determine the genes involved in inflammatory process of diabetic nephropathy. ICAM-1+/+ and ICAM-1-/- mice aged 8 weeks were divided into four groups: 1) nondiabetic ICAM-1+/+ mice (ND-WT), 2) nondiabetic ICAM-1-/- mice (ND-KO), 3) streptozotocin (STZ)-induced diab...
ORGANISM(S): Mus musculus 
2014-10-08 | E-GEOD-21390 | biostudies-arrayexpress
TranscriptomicsThe transcriptional program controlled by Runx1 during early hematopoietic development (expression data)
Transcription factors have long been recognised as powerful regulators of mammalian development, yet it is largely unknown how individual key regulators operate within wider regulatory networks. Here we have used a combination of global gene expression and chromatin-immunoprecipitation approaches a...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-29112 | biostudies-arrayexpress
TranscriptomicsGSK-3alpha Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1-TAB Stabilization and Regulation of Non-Canonical NF-kB
Mutations in KRAS occur in a variety of tumors of epithelial origin, driving the oncogenic phenotype.The NF-kB transcription factor pathway is important for oncogenic RAS to transform cells and to drive tumorigenesis in animal models. Recently TAK1, an upstream regulator of IKK which controls canoni...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-42559 | biostudies-arrayexpress
TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-45118 | biostudies-arrayexpress
TranscriptomicsGene expression profile of Dicer knockout in mouse DP thymocytes
The RNase III enzyme dicer is essential for the processing of microRNAs (miRNAs) and small interfering RNAs (siRNAs) from double-stranded RNA precursors. miRNAs and siRNAs regulate chromatin structure, gene transcription, mRNA stability and translation in a wide range of organisms. To provide a mode...
ORGANISM(S): Mus musculus 
2015-01-28 | E-GEOD-57511 | biostudies-arrayexpress
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