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GenomicsGenome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia
Here we show that pan-haematopoietic ERG expression driven by the Vav promoter induces an early progenitor myeloid leukemia in transgenic mice. Integrated genome-scale analysis of gene expression and ERG binding profiles revealed that ERG activates a transcriptional program similar to human AML stem...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-46554 | biostudies-arrayexpress
MetabolomicsSuboxic DOM is bioavailable to surface prokaryotes in a simulated overturn of an oxygen minimum zone, Devil’s Hole, Bermuda
Oxygen minimum zones (OMZs) are expanding due to increased sea surface temperatures, subsequent increased oxygen demand through respiration, reduced oxygen solubility, and thermal stratification driven in part by anthropogenic climate change. Devil's Hole, Bermuda is a model ecosystem to study OMZ m...
2024-02-27 | MTBLS8122 | MetaboLights
GenomicsA fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation
The aim of this study was to determine the genomic binding sites of important haematopoietic transcription factors in haematopoietic cell lines. 416Bs cells were fixed with either 1 or 0.4 % formaldehyde for 10 mins. Chromatin was isolated, sonicated for 7 mins (30 sec on, 30 sec off), and specific ...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-69776 | biostudies-arrayexpress
TranscriptomicsSAGE tags generated from Triticum aestivum cultivars Scorpion 25 and Xi19 grown under normal and hot/dry conditions
Triticum aestivum cultivars Scorpion 25 and Xi 19 were grown under both normal and hot/dry conditions. We compared the effect of these two growth conditions on these two closely related varieties. We sequenced two biological replicates each for both Scorpion 25 and Xi19 grown under normal conditio...
ORGANISM(S): Triticum aestivum 
2008-09-20 | E-GEOD-12832 | biostudies-arrayexpress
UnknownATHENA (GOG-3020/ENGOT-ov45): a randomized, phase III trial to evaluate rucaparib as monotherapy (ATHENA-MONO) and rucaparib in combination with nivolumab (ATHENA-COMBO) as maintenance treatment following frontline platinum-based chemotherapy in ovarian cancer.
Not available
S-EPMC8666815 | biostudies-literature
GenomicsGenome-wide analysis of GATA1, GATA2, RUNX1, FLI1 and SCL binding in primary human megakaryocytes
We have mapped the binding sites for the five key regulators GATA1, GATA2, RUNX1, FLI1 and TAL1/SCL in primary human megakaryocytes. Statistical analysis identified subsets of enriched as well as depleted combinatorial binding patterns. In particular simultaneous binding by all 5 factors was highly ...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24674 | biostudies-arrayexpress
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
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