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TranscriptomicsP. falciparum Histone Occupancy Mapping
Background: Epigenetic modifications of histones and regulation of chromatin structure have been implicated in regulation of virulence gene families in P. falciparum. To better understand chromatin-mediated gene regulation, we used a high-density oligonucleotide microarray to map the position and en...
ORGANISM(S): Plasmodium falciparum 
2009-12-01 | E-GEOD-18968 | biostudies-arrayexpress
TranscriptomicsImaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
Most malaria drug development focuses on parasite stages detected in red-blood cells even though to achieve eradication next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4,000 commercially availabl...
ORGANISM(S): Plasmodium falciparum 
2011-10-31 | E-GEOD-32485 | biostudies-arrayexpress
TranscriptomicsPlasmodium berghei PbeIK2KO sporozoites
Malaria sporozoites, the form transmitted by mosquitoes, are quiescent while in the insect salivary glands. It is only after the sporozoites are deposited in the host’s skin, migrate to the liver and infect hepatocytes that the parasites continue the life cycle. We show that the sporozoite latency...
ORGANISM(S): Plasmodium berghei 
2010-05-16 | E-GEOD-16259 | biostudies-arrayexpress
ProteomicsEffect of Kinase Inhibitors on Intraerythrocytic Plasmodium falciparum Phosphoproteome
Three flasks of asynchronous blood stage P. falciparum Dd2 culture were grown to ~15% parasitemia, 4% hematocrit using the Trager- Jensen method. Per biological replicate, parasites were treated with 5 x EC50 or EC90 of compound depending on the slope of the EC50 curve for 3 hours. Compounds are DC-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Plasmodium Falciparum Dd2 (ncbitaxon:57267) 
2023-04-03 | MSV000091619 | MassIVE
UnknownRenin-Angiotensin System Blockers and the Risk of COVID-19-Related Mortality in Patients with Kidney Failure.
Not available
S-EPMC8425613 | biostudies-literature
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