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TranscriptomicsGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Previous work has shown that lung tumors and normal-appearing adjacent lung tissues share specific abnormalities that may be highly pertinent to the pathogenesis of lung cancer. However, the global and molecular adjacent airway field cancerization in non-small cell lung cancer (NSCLC) has not been c...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-44077 | biostudies-arrayexpress
UnknownRandomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.
Not available
S-EPMC6085179 | biostudies-literature
TranscriptomicsGene expression profiling of lung adenocarcinomas and normal lung tissue
Lung cancer is still the leading cause of cancer-related deaths in the US and worldwide. Understanding the global molecular profiles or transcriptome of lung cancers would strengthen our understanding of the biology of this malignancy. We performed gene expression profiling using the Human Gene 1.0 ...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-43458 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lung cancer cells transfected with scrambled siRNA and siRNA targeting the ETS2 gene
ETS2 is a canonical transcriptional factor and member of the ETS family of genes. ETS2 binds to consensus ERE binding sites in a broad spectrum of genes thus affecting many intracellular molecular functions. However, the role of ETS2 in the biology and pathogenesis of lung cancers is still not known...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43459 | biostudies-arrayexpress
UnknownExpression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung.
Not available
S-EPMC4874209 | biostudies-literature
TranscriptomicsExpression data for non-small-cell lung cancer
Purpose Prospectively identifying who will benefit from adjuvant chemotherapy (ACT) would improve clinical decisions for individual non-small-cell lung cancer (NSCLC) patients. Most current molecular signatures for lung cancer are prognostic only and provide limited information with regard to the f...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-42127 | biostudies-arrayexpress
UnknownThe BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer.
Not available
S-EPMC5065110 | biostudies-literature
TranscriptomicsAn epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-33072 | biostudies-arrayexpress
TranscriptomicsGene Expression of Malignant Pleural Mesothelioma Tumor and paired Normal Lung tissue
In order to discover critical pathways /networks or therapeutic targets in pleural mesothelioma we profiled 55 tumors along with paired normal tissue (for 41 tumors) using Affymetrix U133 plus 2.0 chips RNA isolated from frozen resected tumor and normal tissues was hybridized to Affymetrix U133 plus...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-51024 | biostudies-arrayexpress
GenomicsIntra-tumor heterogeneity of localized lung adenocarcinomas defined by multi-region sequencing
Background: Intra-tumor heterogeneity (ITH) may have profound impacts on biopsy strategy, characterization of actionable targets, treatment planning, and drug resistance. ITH of lung cancers has not been well studied. Methods: We performed multi-region whole exome sequencing (average sequencing de...
EGAS00001000930 | EGA
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