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TranscriptomicsTranscription profiling by array of temporal gene expression in germinating Clostridium difficile 630 endospores
Clostridium difficile is the leading cause of hospital acquired diarrhoea in industrialised countries. Under conditions that are not favourable for growth, the pathogen produces metabolically dormant endospores via asymmetric cell division. These are extremely resistant to both chemical and physical...
ORGANISM(S): Clostridium difficile 
2013-03-16 | E-BUGS-145 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Mycobacterium smegmatis response to nitrogen stress using bipartite active modules
BACKGROUND: The ability to adapt to environments with fluctuating nutrient availability is vital for bacterial survival. Although essential for growth, few nitrogen metabolism genes have been identified or fully characterised in mycobacteria and nitrogen stress survival mechanisms are unknown. RESUL...
ORGANISM(S): Mycobacterium smegmatis 
2013-06-10 | E-BUGS-140 | biostudies-arrayexpress
TranscriptomicsThe distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country.
Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S. aureus microarray (SAM-62) to compare genomes of isolates from three geographical areas (Belgium, Denmark, and Netherlands) to u...
ORGANISM(S): Staphylococcus aureus 
2012-01-21 | E-BUGS-120 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response
The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been used as a tool to lower intracellular cAMP levels and thereby elucidate the roles of cAMP in mycobacteria. Here we show that levels of cAMP in M. tub...
ORGANISM(S): Mycobacterium tuberculosis 
2013-11-02 | E-BUGS-146 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Neisseria meningitidis Interacting with Human Epithelial Cells in a Long-Term In Vitro Colonization Model
Neisseria meningitidis is a commensal of humans that can colonize the nasopharyngeal epithelium for weeks to months and occasionally invades to cause life-threatening septicemia and meningitis. Comparatively little is known about meningococcal gene expression during colonization beyond those first f...
ORGANISM(S): Neisseria meningitidis 
2013-11-02 | E-BUGS-141 | biostudies-arrayexpress
TranscriptomicsNon-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix
A key feature of Mycobacterium tuberculosis is its ability to become dormant in the host. Little is known of the mechanisms by which these bacilli are able to persist in this state. Therefore, the focus of this study was to emulate environmental conditions encountered by M. tuberculosis in the granu...
ORGANISM(S): Mycobacterium tuberculosis 
2016-11-14 | E-BUGS-142 | biostudies-arrayexpress
TranscriptomicsGene Function Hypotheses for the Campylobacter jejuni Glycome Generated by a Logic-Based Approach.
Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here, we demonstrate the power of a logic-based machine learning approach to propose hypot...
ORGANISM(S): Campylobacter jejuni 
2012-11-04 | E-BUGS-132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection
Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the predominant serotype 3 clone in much of the w...
ORGANISM(S): Streptococcus pneumoniae 
2013-11-02 | E-BUGS-144 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of pneumococcal virulence factors expressed during meningitis in mice
Streptococcus pneumoniae is the most common cause of severe bacterial meningitis in children, the elderly, and immunocompromised individuals. To identify virulence factors preferentially expressed during meningitis, we conducted niche-specific genome-wide in vivo transcriptomic analysis after intran...
ORGANISM(S): Streptococcus pneumoniae 
2012-04-10 | E-BUGS-130 | biostudies-arrayexpress
TranscriptomicsSymmetric Bis-benzimidazoles Are Potent Anti-Staphylococcal Agents with Dual Inhibitory Mechanisms against DNA Gyrase
Various bis-benzimidazole derivatives have been reported to possess activity against Gram-positive pathogens. No mechanism of action has been elucidated to fully account for the antibacterial activity of this class of compounds. A group of symmetric bis-benzimidazoles (BBZ) designed as anticancer ag...
ORGANISM(S): Staphylococcus aureus 
2012-10-14 | E-BUGS-106 | biostudies-arrayexpress
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