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TranscriptomicsTranscription profiling of right ventricule from arrhythmogenic heterozygous plakoglobin deficient mice undergone endurance training to identify transcriptional responses to training.
Endurance training accelerated development of right ventricular dysfunction and arrhythmias in plakoglobin+/- mice. Histology and electron microscopy did not identify right ventricular abnormalities. To identify differences in the transcriptional response to training gene expression profiling was pe...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4120 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats treated with transient focal ischemia
Large clinical studies have shown that AT1 receptor blockers (ARBs) reduce the incidence of stroke in patients at risk. However, there is controversy about the underlying pathomechanisms. To get a closer insight into the effects of ARBs in stroke on molecular level, gene expression pattern was compa...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-4206 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human inflammatory cardiomyopathy vs controls (DCMi) suggests novel therapeutic targets.
Since targeting of specific pathogenic pathways may be more efficient than current unspecific heart failure treatment, we obtained genomewide expression profiles of a DCM subtype characterized by cardiac inflammation (DCMi) in association with parvovirus B19. This study was entirely based on RNA iso...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4172 | biostudies-arrayexpress
TranscriptomicsRAvs.ND
Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthri...
ORGANISM(S): Homo sapiens 
2004-12-10 | E-GEOD-2053 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of pressure overload
Pressure overload (PO) leads first to cardiac hypertrophy and later to heart failure. In mice, PO leads to sex differences in cardiac morphology and function. However, early sex differences in gene regulation that precede sex differences in function have not yet been identified. To identify such c...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6970 | biostudies-arrayexpress
TranscriptomicsFemale sex and oestrogen receptor β attenuate cardiac remodelling and apoptosis in pressure overload
Aims: We investigate sex differences and the role of oestrogen receptor beta (ERbeta) in a mouse model of pressure overload-induced myocardial hypertrophy. Methods and results: We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ER knockout (ERbet...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-18224 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms
Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthri...
ORGANISM(S): Homo sapiens 
2004-11-04 | E-GEOD-1919 | biostudies-arrayexpress
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
UnknownClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Not available
S-EPMC6193486 | biostudies-literature
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