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TranscriptomicsTranscription profiling of mouse Wnt4flox/-;Amhr2tm3(cre)Bhr/+ animals reveals WNT4 is required for ovarian follicle development and female fertility
To study the physiological role of WNT4 in the postnatal ovary, a mouse strain bearing a floxed Wnt4 allele was created and mated to the Amhr2tm3(cre)Bhr strain to target deletion of Wnt4 to granulosa cells. Wnt4flox/-;Amhr2tm3(cre)Bhr/+ mice had significantly reduced ovary weights and produced smal...
ORGANISM(S): Mus musculus 
2009-11-07 | E-GEOD-18704 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human endometrial stromal cells transduced with BMP2- and WNT4-adenovirus.
Our previous studies have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFM-NM-2 superfamily, is markedly induced in human primary endometrial stromal cells (HESC) as they undergo differentiation in response to steroid hormones and cAMP. WNT4 is a downstream target of...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-39949 | biostudies-arrayexpress
TranscriptomicsmiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics result...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress
GenomicsGene expression profiles of Wnt4 high and Wnt4 low populations of murine islets at postnatal day 1 (P1).
Gene expression profiles of Wnt4 high and Wnt4 low populations of murine islets at postnatal day 1 (P1).
PRJNA864809 | ENA
TranscriptomicsTranscription profiling of mouse E14.5 Wnt4 mutants vs wild types
Our laboratory's interest is in understanding the molecular principles that underlie the regional organization of the mammalian metanephric kidney. Our goal is to generate a detailed spatial map of the cellular expression of selected regulatory genes during mammalian kidney development. The goal of...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6288 | biostudies-arrayexpress
GenomicsCell intrinsic Wnt4 influences cDC fate determination to suppress Type 2 immunity
Cell intrinsic Wnt4 influences cDC fate determination to suppress Type 2 immunity
PRJNA544073 | ENA
TranscriptomicsGene expression profiles of Wnt4 high and Wnt4 low populations of murine islets at postnatal day 1 (P1).
To find the differences between β cells expressing Wnt4 and those that do not express it (or express it at low levels) at neonatal stage, murine islets at postnatal day 1 (P1) were collected. Based on a reporter expressing Cre recombinase from the Wnt4 locus, we observed that Wnt4 expression starts ...
ORGANISM(S): Mus musculus 
2022-08-02 | GSE210237 | GEO
TranscriptomicsTranscription profiling of mouse developing kidney to investigate Wnt4-dependent gene expression (GUDMAP Series_id: 13)
Our laboratory's interest is in understanding the molecular principles that underlie the regional organization of the mammalian metanephric kidney. Our goal is to generate a detailed spatial map of the cellular expression of selected regulatory genes during mammalian kidney development. The goal of...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6934 | biostudies-arrayexpress
GenomicsReduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome
Reduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome
PRJNA1121200 | ENA
TranscriptomicsWNT4 is required for ovarian follicle development and female fertility
To study the physiological role of WNT4 in the postnatal ovary, a mouse strain bearing a floxed Wnt4 allele was created and mated to the Amhr2tm3(cre)Bhr strain to target deletion of Wnt4 to granulosa cells. Wnt4flox/-;Amhr2tm3(cre)Bhr/+ mice had significantly reduced ovary weights and produced smal...
ORGANISM(S): Mus musculus 
2009-10-23 | GSE18704 | GEO
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