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ProteomicsA systematic screen of archaeal MazF proteins reveals Tth-MazF1, a versatile, sequence-specific ribonuclease from Thermococcus thioreducens.
Nucleotide- and sequence-specific ribonucleases are essential tools for dissecting RNA structure, modification, and composition, yet the enzymatic repertoire available for high-resolution RNA analysis remains limited. Here, we systematically screened 186 MazF homologs, including 164 from archaeal or...
ORGANISM(S): Thermococcus thioreducens 
2026-05-25 | PXD067005 | Pride
Thermococcus thioreducens rna lc-ms/ms 
ProteomicsHuman RNase 4 Improves mRNA Sequence Characterization by LC-MS/MS.
With the rapid growth of synthetic messenger RNA (mRNA)-based therapeutics and vaccines, the development of analytical tools for characterization of long, complex RNAs has become essential. Tandem liquid chromatography-mass spectrometry (LC-MS/MS) permits direct assessment of the mRNA primary sequen...
ORGANISM(S): synthetic RNA 
2022-07-26 | PXD033334 | Pride
Mrna  human rnase4 
UnknownCytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort.
Not available
S-EPMC9279437 | biostudies-literature
TranscriptomicsGene Profiling in the Livers of Wild-Type and PPARalpha-Null Mice Exposed to Perfluorooctanoic Acid (PFOA)
Unlike the PPARalpha agonist W14,643, PFOA is capable of inducing effects independently of PPARa. Genes altered in the PPARalpha-null mouse following exposure to PFOA included those associated with fatty acid metabolism, inflammation, xenobiotic metabolism, and cell cycle progression. The specific s...
ORGANISM(S): Mus musculus 
2008-05-22 | E-GEOD-9796 | biostudies-arrayexpress
UnknownIdentification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen.
Not available
S-EPMC7986981 | biostudies-literature
GenomicsBreast Cancer Cell Line Data Access Committee
Access to data is available by emailing application to the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000015 | EGA
TranscriptomicsA Sleeping Beauty Forward Genetic Screen Identifies Genes Promoting Osteosarcoma Development and Metastasis
A Sleeping Beauty (SB) transposon forward genetic screen was performed to identify the genes that promote osteosarcoma (OS) development and metastasis. Mutagenesis induced OS in wild type mice and accelerated it on a Trp53 deficient background. Analysis of tumors demonstrated that Trp53 deficiency ...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-58770 | biostudies-arrayexpress
GenomicsEGAD00000000119
Genotypes from cell lines derived from breast carcinoma tissue
EGAD00000000119 | EGA
GenomicsAssessment of genomic copy number alterations in breast cancer
The aim of this study was to assess genomic copy number alterations in a panel of breast cancer cell lines. These data were used to identify common aberrations associated with breast cancer, and also to identify aberrations associated with response to therapeutic compounds.
EGAS00000000059 | EGA
GenomicsCHARGE
Aggregate results from a case-control study on stroke and ischemic stroke.
EGAD00000000029 | EGA
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