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ProteomicsA systematic screen of archaeal MazF proteins reveals Tth-MazF1, a versatile, sequence-specific ribonuclease from Thermococcus thioreducens.
Nucleotide- and sequence-specific ribonucleases are essential tools for dissecting RNA structure, modification, and composition, yet the enzymatic repertoire available for high-resolution RNA analysis remains limited. Here, we systematically screened 186 MazF homologs, including 164 from archaeal or...
ORGANISM(S): Thermococcus thioreducens 
2026-05-25 | PXD067005 | Pride
Thermococcus thioreducens rna lc-ms/ms 
ProteomicsHuman RNase 4 Improves mRNA Sequence Characterization by LC-MS/MS.
With the rapid growth of synthetic messenger RNA (mRNA)-based therapeutics and vaccines, the development of analytical tools for characterization of long, complex RNAs has become essential. Tandem liquid chromatography-mass spectrometry (LC-MS/MS) permits direct assessment of the mRNA primary sequen...
ORGANISM(S): synthetic RNA 
2022-07-26 | PXD033334 | Pride
Mrna  human rnase4 
ProteomicsComprehensive Nucleoside Analysis of Archaeal RNA Modification Profiles Reveals a m7G in the Conserved P-loop of 23S rRNA
Extremophilic archaea employ diverse chemical RNA modifications, providing a rich source of new enzymes for biotechnologically valuable RNA manipulations. Our understanding of the modified nucleoside profiles in Archaea, as well as the functions and dynamic regulation of specific RNA modifications i...
ORGANISM(S): Thermococcus kodakarensis 
2025-02-12 | PXD060644 | Pride
Rna modifications Archaea Lc-ms/ms 
UnknownGlobal age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535839 | biostudies-literature
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