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TranscriptomicssnRNA-seq of whole hearts from adult fzt:DU mice
We used snRNA-seq to investigate for the first time an entire adult mammalian heart. To avoid potential aberrations due to inbreeding, we relied on an outbred mice strain (Fzt:DU) (Dietl, G.; Langhammer, M.; Renne, U. Model simulations for genetic random drift in the outbred strain Fzt:DU. Arch. Ani...
ORGANISM(S): Mus musculus 
2020-02-22 | E-MTAB-8751 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of whole hearts from adult BL6 mice
We used snRNA-seq to investigate an entire adult mammalian heart of BL6 mice. Whole hearts were harvested from 4 male mice (12 weeks) after cervical dislocation. The hearts were pooled and nuclei isolated using the Nuclei PURE Prep isolation kit (Sigma-Aldrich, Darmstadt, Germany) according to the m...
ORGANISM(S): Mus musculus 
2020-03-16 | E-MTAB-8848 | biostudies-arrayexpress
TranscriptomicsMicroarray data for C57BL/6J and B6.Rag2del mice after cardiomyocyte transplantation
We compared the molecular outcome following cardiomyocyte transplantation in blood and heart tissue in wildtype and T- and B cell deficient Rag2del mice. Our results demonstrate that the improved functional outcome following cardiomyocyte transplantation is dependent on a specific CCR2 macrophage re...
ORGANISM(S): Mus musculus 
2023-07-07 | E-MTAB-13152 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Seq of entire ventricles of C57BL/6J and B6.Rag2del mice after myocardial infarction
We compared the cellular and molecular outcome following permanent LAD ligation in wildtype and T- and B cell deficient Rag2del mice. Our results demonstrate that the significant changes in the cardiac immune response following myocardial infarction (MI). 8-12 weeks old, male and female C57BL/6J mic...
ORGANISM(S): Mus musculus 
2023-07-20 | E-MTAB-13147 | biostudies-arrayexpress
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