Sort   by:  
 Page size 
TranscriptomicsFibroblast-specific focal adhesion kinase links mechanical force to fibrosis via chemokine-mediated inflammatory pathways
Hypertrophic scar (HTS) formation is characterized by exuberant fibroproliferation for reasons that remain poorly understood1. One important but often overlooked component of wound repair is mechanical force, which regulates reciprocal cell-matrix interactions through focal adhesion components inclu...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26390 | biostudies-arrayexpress
TranscriptomicsFrequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Inflammatory hepatocellular adenomas (IHCA) are benign liver tumours defined by the presence of inflammatory infiltrates and by the elevated expression of inflammatory proteins in tumour hepatocytes1,2. Here we show a striking activation of the IL6 signalling pathway in this tumour type, and sequenc...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-11819 | biostudies-arrayexpress
TranscriptomicsMultiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficie...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-14245 | biostudies-arrayexpress
MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
TranscriptomicsPatterns of histone H3 Lysine 27 monomethylation and erythroid cell-type specific gene expression [expression]
ERYTHROID CELL-TYPE SPECIFIC GENE EXPRESSION Post-translational histone modifications, acting alone or in a context-dependent manner, influence numerous cellular processes via their regulation of gene expression. Monomethylation of histone H3 lysine 27 (K27me1) is a poorly understood histone modific...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-32135 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human sensitive and resistant tumours identify gene expression patterns in primary breast-cancer specimens that might predict response to taxanes.
These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume.
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-349 | biostudies-arrayexpress
TranscriptomicsDevelopment of Transcriptomic Biomarker Signature in Human Saliva to Detect Lung Cancer
Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to profile transcriptomes and discover altered gene expression in saliva supernatant. Salivary transcriptomic biomarker discovery was performed on 10 lung cancer patients and 10 matched controls. Seven messenger RNA biomarkers ...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-32175 | biostudies-arrayexpress
MetabolomicsAberrant accumulation of cyclin D1 rewires glutamine metabolism via loss of IDH3 generating metabolic vulnerability in ESCC and HNSCC

Excessive cyclin D1 accumulation is a frequent oncogenic event in head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC). Although classically associated with enhanced proliferation and genomic instability, we reveal that cyclin D1 dysregulation induces unexpe...

2026-08-24 | MTBLS13687 | MetaboLights
TranscriptomicsCharacterization of the starvation response in the Arabidopsis dcl1-9 mutant
The SnRK1 protein kinase, the plant ortholog of mammalian AMPK and yeast Snf1, is activated by the energy depletion caused by adverse environmental conditions. Upon activation, SnRK1 triggers extensive transcriptional changes to restore homeostasis and promote stress tolerance and survival partly th...
ORGANISM(S): Arabidopsis thaliana 
2013-07-15 | E-GEOD-46713 | biostudies-arrayexpress
TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
Sort   by:  
 Page size