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MetabolomicsLipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia
Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from142 patients with CAP (CAP...
2016-08-11 | MTBLS354 | MetaboLights
TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsWild Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell survival
Loss of Pten in the KrasG12D;Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas. Tumors occur with 100% penetrance and express elevated expression of wild type tumor repressor protein 53 (TRP...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-34882 | biostudies-arrayexpress
TranscriptomicsExpression data from lung adenocarcinoma mouse tumors
To identify altered signal transduction pathways involved in the progression and metastases of Lkb1 deficient lung tumors, we have performed an unbiased microarray analysis of primary and metastatic mouse lung tumors We used microarrays to detail the global programme of gene expression underlying m...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21581 | biostudies-arrayexpress
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
TranscriptomicsTumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases
The functional status of the tumor repressor protein (TP53 or TRP53) is a defining feature of ovarian cancer. Mutant or null alleles of TP53 are expressed in greater than 90% of all high-grade serous adenocarcinomas. Wild type TP53 is elevated in low-grade serous adenocarcinomas in women and in our ...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-51095 | biostudies-arrayexpress
UnknownSynergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers.
Purpose:KRAS-activating mutations are the most common oncogenic driver in non-small cell lung cancer (NSCLC), but efforts to directly target mutant KRAS have proved a formidable challenge. Therefore, multitargeted therapy may offer a plausible strategy to effectively treat KRAS-...
S-EPMC5690829 | biostudies-literature
UnknownSerial single-cell profiling analysis of metastatic TNBC during Nab-paclitaxel and pembrolizumab treatment.

Purpose

Immunotherapy has recently been shown to improve outcomes for advanced PD-L1-positive triple-negative breast cancer (TNBC) in the Impassion130 trial, leading to FDA approval of the first immune checkpoint inhibitor in combination with taxane chemotherapy. To further develop predictiv...
S-EPMC8170702 | biostudies-literature
UnknownCombined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC.
SHP2 inhibitors (SHP2i) alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. SHP2 plays critical roles in normal cell signaling; hence, SHP2is could influence the tumor microenvironment. We found that SHP2i treatment depleted alveolar and ...
S-EPMC8758507 | biostudies-literature
UnknownEpigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non-Small Cell Lung Cancer.
Despite advancements in treatment options, the overall cure and survival rates for non-small cell lung cancers (NSCLC) remain low. While small-molecule inhibitors of epigenetic regulators have recently emerged as promising cancer therapeutics, their application in patients with NSCLC is limited. To ...
S-EPMC7493834 | biostudies-literature
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