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TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
UnknownGeneration of Sex-Reversed Female Clonal Mice via CRISPR-Cas9-Mediated Y Chromosome Deletion in Male Embryonic Stem Cells.
Not available
S-EPMC7898403 | biostudies-literature
UnknownA randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.
Not available
S-EPMC5947654 | biostudies-literature
UnknownPentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Not available
S-EPMC6985668 | biostudies-literature
UnknownA dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Not available
S-EPMC7062187 | biostudies-literature
UnknownImmunogenicity of COVID-19 vaccines and levels of SARS-CoV-2 neutralising antibody in the Bruneian population: Protocol for a national longitudinal study.
Not available
S-EPMC9716409 | biostudies-literature
UnknownAssociation between duration of smoking abstinence before non-small-cell lung cancer diagnosis and survival: a retrospective, pooled analysis of cohort studies.
Not available
S-EPMC10540150 | biostudies-literature
Genomics4dbf9af0-d667-494b-b3d9-c80c112d0527 - samples
high depth WGS sequencing of 8 sites of a RET fusion tumour
EGAD00001006878 | EGA
Genomicsdc7d6e29-28d7-43ec-895c-d530c18112cf - samples
Deep WGS sequencing (160x) of 2 different sites of disease of a patient with a RET fusion positive cancer. Amplicon sequencing of 19 other sites of the same patients for the RET fusion.
EGAD00001005776 | EGA
GenomicsMulti-regional tumour biopsies of a RET fusion patient
Identifying modes of resistance to a new experimental drug for a patient resistant to other therapies
EGAS00001004023 | EGA
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