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TranscriptomicsImplications of time-series gene expression profiles of replicative senescence
Although senescence has long been implicated in aging-associated pathologies, it is not clearly understood how senescent cells are linked to these diseases. To address this knowledge gap, we profiled cellular senescence phenotypes and mRNA expression patterns during replicative senescence in human d...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-41714 | biostudies-arrayexpress
TranscriptomicsProfiling of exome mutations associated with progression of HBV-related hepatocellular carcinoma
We profiled the mutations and gene expressions of early and advanced hepatocellular carcinoma (HCC) related with Hepatitis B-viral infection. Integrative analysis was performed with whole-exome sequencing and gene expression profiles of the 12 cases of early and advanced HCCs and paired non-tumoral ...
ORGANISM(S): Homo sapiens 
2014-10-19 | E-GEOD-62441 | biostudies-arrayexpress
TranscriptomicsIdentification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression
Many cancer cells require more glycolytic adenosine triphosphate production due to a mitochondrial respiratory defect. However, the roles of mitochondrial defects in cancer development and progression remain unclear. To address the role of transcriptomic regulation by mitochondrial defects in liver ...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-64505 | biostudies-arrayexpress
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