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MetabolomicsMetabolomic profiling of Fraxinus excelsior genotypes tolerant or susceptible to ash dieback disease reveals changes in iridoid glycosides
European common ash, Fraxinus excelsior L., is currently threatened by Ash dieback (ADB) caused by the fungus, Hymenoscyphus fraxineus. To detect and identify metabolites that may be products of pathways important in contributing to resistance against H. fraxineus we performed untargeted metabolomic...
2016-11-09 | MTBLS372 | MetaboLights
TranscriptomicsGene expression analysis of late exponential vs. stationary phase cultures using a custom designed Pseudo-nitzschia multiseries (Ps-n) cDNA microarray
Pseudo-nitzschia multiseries (Ps-n) is a toxigenic marine diatom that produces the neurotoxin, domoic acid. We screened for candidate genes that may be involved in domoic acid production by determining changes in transcript profiles in Ps-n cultures that were in late exponential (low-domoic-acid-pro...
ORGANISM(S): Pseudo-nitzschia multiseries 
2013-09-08 | E-GEOD-46845 | biostudies-arrayexpress
TranscriptomicscDNA Microarray 1: Compression Xylem vs. Opposite Xylem
The within-tree variation in wood properties constitutes an exceptional model to study the mechanisms that adjust the different biosynthetic pathways providing substrates with the massive and variable demands of different biosynthetic reactions of cell wall polymers. Although a few genes have been r...
ORGANISM(S): Pinus pinaster 
2012-05-05 | E-GEOD-37678 | biostudies-arrayexpress
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
TranscriptomicscDNA Microarray 2: Compression Xylem vs. Opposite Xylem
The within-tree variation in wood properties constitutes an exceptional model to study the mechanisms that adjust the different biosynthetic pathways providing substrates with the massive and variable demands of different biosynthetic reactions of cell wall polymers. Although a few genes have been r...
ORGANISM(S): Pinus pinaster 
2012-05-05 | E-GEOD-37736 | biostudies-arrayexpress
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
UnknownGenetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.
Not available
S-EPMC6192855 | biostudies-literature
UnknownEstablishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.
Not available
S-EPMC10918877 | biostudies-literature
TranscriptomicsThe Populus transciptome in elevated CO2 reveals increased anthocyanin biosynthesis during delayed autumnal senescence
Over recent decades the progression of natural autumnal senescence has been increasingly delayed across wide areas of the Northern Hemisphere and is thought to be caused by rising temperature. Recently this delay has been shown to be partly attributable to rising atmospheric carbon dioxide concentr...
ORGANISM(S): Populus x canadensis 
2010-01-31 | E-GEOD-15874 | biostudies-arrayexpress
UnknownRare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome.
Not available
S-EPMC5568251 | biostudies-literature
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