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ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
TranscriptomicsGene expression profile of TGFβ3 stimulation and TRPV4 activation/inhibition in the TC28a2 human chondrocyte cell line
RNA-seq of TC28a2 cells following TRPV4 activation/inhibition in the presence and absence of prior TGFβ3 stimulation. The experiment was performed to determine the effect of TRPV4 activity on gene expression in the presence and absence of TGFβ stimulation. TGFβ3 was used to stimulate TGFβ signalling...
ORGANISM(S): Homo sapiens 
2022-01-17 | E-MTAB-10279 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of MED patient-derived (MATN3 V194D) and unaffected iPSC-chondrogenesis
PBMCs from MED patients carrying the MATN3 V194D mutation and unaffected controls were reprogrammed into hiPSCs. Samples were differentiated into Day 21 cartilage pellets via an iMSC intermediate.
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16600 | biostudies-arrayexpress
TranscriptomicsTranscriptomic time-series of human embryonic stem cell differentiation to hypertrophic-like chondrocytes via a mesenchymal intermediate
This study characterizes the gene expression changes during the differentiation of the human embryonic stem cell (hESC) line Man13 into hypertrophic-like cartilage pellets. Samples include five key stages: pluripotent cells (TeSR™-E8™), induced mesenchymal stromal cells (iMSCs), and three-dimensiona...
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16597 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of MED patient-derived (MATN3 T195K) and unaffected iPSC-chondrogenesis
PBMCs from MED patients carrying the MATN3 T195K mutation and unaffected controls were reprogrammed into hiPSCs using Sendai virus. Data includes three differentiation stages: pluripotent hiPSCs, iMSCs, and Day 21 cartilage pellets. Sequencing was performed at the University Genomics Core Facility.
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16598 | biostudies-arrayexpress
TranscriptomicsGene expression profile of control and CRISPR-edited MATN3 V194D mutant Day 21 cartilage pellets differentiated from the human ESC line MAN13
RNA-seq of control and MATN3 V194D mutant cartilage pellets. The MATN3 V194D mutation was introduced using CRISPR-Cas9 in pluripotent cells before differentiation through an iMSC intermediate to Day 21 cartilage pellets.
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16599 | biostudies-arrayexpress
TranscriptomicsNovel genes in Sitka spruce associated with wood density identified from global transcriptomic analysis
The current study uses a transcriptomic approach to identify genes associated with differences in wood density, that are likely to be of value as candidate genes in Sitka breeding programmes for improved wood density. Following extensive wood density analysis from a Sitka spruce (Picea sitchensis (B...
ORGANISM(S): Picea sitchensis 
2010-05-07 | E-GEOD-18579 | biostudies-arrayexpress
UnknownTherapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload.
Not available
S-EPMC4631316 | biostudies-literature
ProteomicsIdentification and characterization of mutations in ZBTB33 in clonal hematopoiesis and myelodysplastic syndromes
Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Galli A, Castellano CA, McConkey M, Tarun A, Wong W, Schenone M, Stanclift C, Tanenbaum B, Malolepsza E, Nilsson B, Bick AG, Weinstock JS, Miller M, Niroula A, Dunford A, Taylor-Weiner A, Wood T, Barbera A, Anand S, Psaty BM, Des...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-26 | MSV000087304 | MassIVE
UnknownShort-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
Not available
S-EPMC6931063 | biostudies-literature
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