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TranscriptomicsRARA haploinsufficiency modestly influences the phenotype of APL.
RARA haploinsufficiency is an invariable consequence of t(15;17) reciprocal translocations in acute promyelocytic leukemia (APL). Furthermore, retinoids and RARA activity have been implicated in hematopoietic self-renewal, lineage commitment and neutrophil maturation. We and others therefore predict...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-23291 | biostudies-arrayexpress
TranscriptomicsEffect of Protease-resistant PML-RARα on the leukemogenic potential in a mouse model of Acute Promyelocytic Leukemia
Previous studies in our laboratory demonstrated that the azurophil granule protease neutrophil elastase (NE) cleaves PML-RARA (PR), the fusion protein that initiates acute promyelocytic leukemia (APL). Further, NE deficiency reduces the penetrance of APL in a murine model of this disease. We therefo...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-21550 | biostudies-arrayexpress
TranscriptomicsExpression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice
Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed myeloid precursor (e.g., a promyelocyte) vs. a hematopoietic stem/progenitor cell (HSPC). We original...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-40022 | biostudies-arrayexpress
TranscriptomicsmCG-PML-RARA alters multipotent hematopoiesis.
Acute promyelocytic leukemia (APL) is associated with PML-RARA expression and late myeloid maturation arrest. The myeloid restriction of PML-RARA dependent leukemia has been recapitulated in multiple mouse models of APL, including PML-RARA expressed from the Ctsg locus (mCG-PR). However, we report h...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-24728 | biostudies-arrayexpress
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