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MetabolomicsClovamide, a hydroxycinnamic acid amide, is a resistance factor against Phytophthora spp. in Theobroma cacao
The hydroxycinnamic acid amides (HCAAs) are a diverse group of plant specialized phenylpropanoid metabolites distributed widely in the plant kingdom and are known to be involved in tolerance to abiotic and biotic stress. The HCAA clovamide is reported in a small number of distantly related species. ...
2020-12-17 | MTBLS2154 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
MetabolomicsA robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling
BACKGROUND: Neutrophils are phagocytic innate immune cells that play essential roles in host defence, but are also implicated in inflammatory diseases such as rheumatoid arthritis (RA) where they contribute to systemic inflammation and joint damage. Transcriptomic analysis of neutrophils has reveale...
2018-12-06 | MTBLS658 | MetaboLights
MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
TranscriptomicsTranscription profiling of human colorectal carcinoma-derived cell lines, p53 -/-, +/-, +/+ at 0 and 12 hrs after growth arrest
Human colorectal carcinoma-derived cell lines, p53 -/-, +/-, +/+ at 0 and 12 hrs after growth arrest.
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-90 | biostudies-arrayexpress
MetabolomicsMaternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiolo...
2024-06-27 | MTBLS2245 | MetaboLights
UnknownInference Under a Wright-Fisher Model Using an Accurate Beta Approximation.
Not available
S-EPMC4649640 | biostudies-literature
TranscriptomicsTranscription profiling time series of Campylobacter jejuni reveals a stationary phase physiological switch
Growth curves of C. jejuni NCTC11168 were performed in BHI broth at 42C with agitation at 150rpm.o. At 16, 20, 40, 46 and 54 hours of growth, aliquots were removed from the culture, and the bacteria were mixed with RNA stabilisation agent. RNA was then extracted from the stabilised pellets, and tre...
ORGANISM(S): Campylobacter jejuni 
2008-08-30 | E-MEXP-1436 | biostudies-arrayexpress
ModelsLorenz2026 - Wright-Fisher model with negative frequency-dependent selection (NFDS) for vaccine-replacement dynamics in S. pneumoniae
A compartmental Wright-Fisher model that describes the replacement dynamics in Streptococcus pneumoniae populations after the introduction of vaccines. Free parameters in the model are vaccine impact, negative frequency-dependent selection (NFDS), and immigration rate.
2026-09-27 | MODEL2609210001 | BioModels
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