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MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
UnknownUnsaturated glycerophospholipids mediate heme crystallization: biological implications for hemozoin formation in the kissing bug Rhodnius prolixus.
Not available
S-EPMC3935856 | biostudies-literature
UnknownMaternal stress in relation to sex-specific expression of placental genes involved in nutrient transport, oxygen tension, immune response, and the glucocorticoid barrier.
Not available
S-EPMC7306440 | biostudies-literature
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
ProteomicsAmino acid and heavy water labelling to obtain protein turnover rates in intact adult animals
Both labelling studies were conducted with C57/BL6J adult male mice, derived from the same supplier and maintained under identical conditions. Eleven adult male C57BL/6JOlaHsd mice (Harlan UK Ltd., Shardlow, UK) of over 12 months of age at the start of the experiment were housed individually in 48 x...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-13 | PXD029639 | JPOST Repository
UnknownMulticenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue.
Not available
S-EPMC9469467 | biostudies-literature
UnknownRule-out test for autism using machine-learning analysis of molecular temporal dynamics in hair - a multicenter study.
Not available
S-EPMC12668059 | biostudies-literature
UnknownUncovering system-specific stress signatures in primate teeth with multimodal imaging.
Not available
S-EPMC4698674 | biostudies-literature
UnknownInvestigating change across time in prevalence or association: the challenges of cross-study comparative research and possible solutions.
Not available
S-EPMC9613735 | biostudies-literature
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