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MetabolomicsWT 2.0: Unveiling the “dark matter” in the metabolome using all-ion stepwise fragmentation acquisition mode (ASFAM) and deep learning-based feature extraction

Current metabolomics methods often miss low-abundance compounds and yield incomplete or ambiguous MS2 spectra, resulting in the presence of “dark matter” within the metabolome. Here, we introduce WT 2.0, which employs an all-ion stepwise fragmentation acquisition mode (ASFAM) to acquire comprehe...

2025-09-23 | MTBLS13023 | MetaboLights
MetabolomicsMetabolic study of BRCA1 knockout cells and WT cells in homo sapiens

BRCA1 mutations are a hallmark of hereditary ovarian cancer, strongly linked to deficiencies in homologous recombination (HR) DNA repair and impaired DNA replication fork protection. However, its roles in cancer progression beyond maintaining genomic integrity remain poorly understood. Through me...

2026-05-15 | MTBLS12245 | MetaboLights
MetabolomicsTargeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...
2026-03-12 | MTBLS12512 | MetaboLights
Metabolomicsdb/db WT ozone and air exposed mice
Not available
ORGANISM(S): Mus musculus 
ST000815 | MetabolomicsWorkbench
MetabolomicsTargeted metabolomics analysis of WT and GSDMDKO macrophages
Not available
ORGANISM(S): Mus musculus 
ST002378 | MetabolomicsWorkbench
MetabolomicsMetabolomics study comparing SCAP KO and WT B cells
Not available
ORGANISM(S): Mus musculus 
ST002322 | MetabolomicsWorkbench
MetabolomicsBasic Metabolism Studies (wt and TPA null)
Not available
ORGANISM(S): Mus musculus 
ST000160 | MetabolomicsWorkbench
MetabolomicsGLS2KO vs WT mouse hepatocytes
Not available
ORGANISM(S): Mus musculus 
ST001952 | MetabolomicsWorkbench
MetabolomicsStable isotope-resolved metabolomics of WT, GYG1 KO, and GYG2 KO human embryonic stem cells using 13C-labeled glucose and palmitate
Proper regulation of glycogen metabolism is fundamental to cellular energy homeostasis, and its disruption is associated with various metabolic disorders, including glycogen storage diseases (GSDs) and potentially diabetes. Despite glycogen’s role as an essential energy reservoir, the mechanisms gov...
2025-07-15 | MTBLS12586 | MetaboLights
MetabolomicsComparative metabolomics study of WT and iButOH tolerant E. coli
Not available
ORGANISM(S): Escherichia coli 
ST000173 | MetabolomicsWorkbench
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