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MetabolomicsMetabolic study of BRCA1 knockout cells and WT cells in homo sapiens

BRCA1 mutations are a hallmark of hereditary ovarian cancer, strongly linked to deficiencies in homologous recombination (HR) DNA repair and impaired DNA replication fork protection. However, its roles in cancer progression beyond maintaining genomic integrity remain poorly understood. Through me...

2026-05-15 | MTBLS12245 | MetaboLights
MetabolomicsTargeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...
2026-03-12 | MTBLS12512 | MetaboLights
TranscriptomicsMEF-mKras-WT1
K-ras is one of the most frequently mutated human oncogenes. Activation of K-ras can lead to either senescence or proliferation in primary cells. The precise mechanism governing these distinct outcomes remains unclear. Here we utilized a loss-of-function screen to assess the role of specific genes ...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-15325 | biostudies-arrayexpress
TranscriptomicsClassification of a frameshift/extended and a stop mutation in WT1 as gain of function mutations which activate cell cycle genes and promote Wilms tumor cell proliferation
The Wilms tumor 1 (WT1) gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumor development and an oncogene for diverse malignant tumors. We recently established cell lines from primary Wilms tumors and identified the corresponding...
ORGANISM(S): Homo sapiens 
2014-05-12 | E-GEOD-54635 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human WT1-mutant versus WT1 wild-type Wilms tumors
Gain-of-function mutations in exon 3 of beta-catenin (CTNNB1) are specific for Wilms' tumors that have lost WT1, but 50% of WT1-mutant cases lack such "hot spot" mutations. To ask whether stabilization of beta-catenin might be essential after WT1 loss, and to identify downstream target genes, we com...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6120 | biostudies-arrayexpress
MetabolomicsStable isotope-resolved metabolomics of WT, GYG1 KO, and GYG2 KO human embryonic stem cells using 13C-labeled glucose and palmitate
Proper regulation of glycogen metabolism is fundamental to cellular energy homeostasis, and its disruption is associated with various metabolic disorders, including glycogen storage diseases (GSDs) and potentially diabetes. Despite glycogen’s role as an essential energy reservoir, the mechanisms gov...
2025-07-15 | MTBLS12586 | MetaboLights
TranscriptomicsEWS-WT1 Oncogene Activates a Neuronal Reprogramming Factor ASCL1 and Mediates Partial Neural Differentiation
A chromosomal translocation fusion gene product EWS-WT1 is the defining genetic event in Desmoplastic Small Round Cell Tumor (DSRCT), a rare but aggressive tumor with a high rate of mortality. EWS-WT1 oncogene acts as an aberrant transcription factor that drives tumorigenesis, but the mechanism by w...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-53301 | biostudies-arrayexpress
MetabolomicsMetabolomics analysis of WT vs. GOT1 knockout CD8+ T cells
Not available
ORGANISM(S): Mus musculus 
ST002374 | MetabolomicsWorkbench
Metabolomics[U-13C]glutamine tracing in activated WT, GOT1 or GLUD1 knockout CD8+ T cells
Not available
ORGANISM(S): Mus musculus 
ST002365 | MetabolomicsWorkbench
Metabolomics[U-13C]glucose tracing in activated WT, GOT1 or GLUD1 knockout CD8+ T cells
Not available
ORGANISM(S): Mus musculus 
ST002364 | MetabolomicsWorkbench
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