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ProteomicsSUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation
Protein inhibitor of activated STAT (PIAS) are E3 SUMO ligases playing important roles in protein stability and signaling transduction pathways. PIAS proteins are overexpressed in the triple-negative breast cancer cell line MDA-MB-231, and PIAS knockout (KO) results in a reduction in cell proliferat...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD023841 | Pride
Hek293 sumo3m lc-ms/ms pias sumo e3 ligase proteomics 
ProteomicsA classic famous prescription alleviates inflammation in CUMS model mice via modulating MYDGF/MAP4K4/NF-κB signaling pathway, verified through UPLC-HRMS and proteomics analysis
Major depressive disorder (MDD) has caused a heavy burden on society and affected over 350 million patients worldwide currently. However, there have been 30-50% MDD patients with non-response to antidepressants. Chronic unpredictable mild stress (CUMS) has been considered as a critical trigger facto...
ORGANISM(S): Mus Sp. 
2024-06-25 | PXD053391 |
ProteomicsPPTC7 integrates homeostatic and physiological signals to regulate mitophagy and mitochondrial mass
Here we report that knockout of PPTC7, a mitochondrial matrix protein, hyperactivates BNIP3/NIX-mediated mitophagy in vitro and in vivo. Biochemically, the PPTC7 precursor is trapped by BNIP3 and NIX to mitochondrial outer-membrane, where PPTC7 scaffolds the assembly of the substrate-PPTC7- SCFFBXL4...
ORGANISM(S): Homo Sapiens 
2023-06-05 | PXD042744 |
ProteomicsCopper exposure aggravates motor phenotype via inhibiting mitophagy in SOD1G93A transgenic mice
Background Amyotrophic lateral sclerosis (ALS) is an age-dependent and incurable neurodegenerative disease. It is pathologically characterized by selective degeneration of motor neurons resulting in a catastrophic loss of motor function. Previous studies showed that excess copper (Cu) might have a r...
ORGANISM(S): Mus Musculus 
2023-01-29 | PXD039728 |
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