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ProteomicsProteomic and metabolomic studies of transplanted gastric epithelial cell mitochondria in reducing gastric cancer cell malignancy
Mitochondria exhibit diverse effects on cellular responses. Mitochondrial transplantation from gastric epithelial cells GES-1 to gastric cancer cells AGS reduces cancer malignancy was previously reported. We employed proteomic and metabolomic analyses to elucidate underlying mechanisms. iTRAQ/TMT-ba...
ORGANISM(S): Homo sapiens (Human) 
2026-05-18 | PXD061705 | Pride
Metabolomics Mitochondrial transplantation Proteomics Gastric cancer Pyruvate 
TranscriptomicsGene expression profiling in BCR/ABL-expressing LSCs and BCR/ABL-expressing Hif1a-/-LSCs
Using a mouse model of chronic myelogenous leukemia (CML), here we report that HIF1M-NM-1 plays a crucial role in survival maintenance of leukemia stem cells (LSCs). Deletion of HIF1M-NM-1 impairs the propagation of CML through impairing cell cycle progression and inducing apoptosis of LSCs. Deletio...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35111 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild type and Hif1a-deficient normal and leukemia stem cells
This SuperSeries is composed of the following subset Series: GSE35110: Gene expression profiling in WT and Hif1a-/- HSCs GSE35111: Gene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Hif1a-/-LSCs Refer to individual Series
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35183 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR-ABL expressing LSCs and BCR-ABL-BLK expressing LSCs
Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for leukemia stem cells (LSCs), we showed that BCR-ABL down-regulates the B lymphoid kinase (Blk) gene in leukemia stem cells in CML mice and that Blk functions as a tumor suppressor in LSCs and suppresses LSC function. Inhibiti...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-36096 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Alox5-/-LSCs
We previously demonstrated that Alox5 deficiency impairs the function of LSCs and prevents the initiation of BCR-ABL-induced CML. To identify the pathways in which Alox5 gene regulates function of LSCs, we performed a comparative DNA microarray analysis using total RNA isolated from non-BCR-ABL-expr...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29347 | biostudies-arrayexpress
GenomicsPolycomb Cbx orthologs mediate the balance between Hematopoietic Stem Cell self-renewal and differentiation
By genome-wide ChIP-seq analyses we show that Cbx7 and Cbx8 share ~95% of their targets in bone marrow cells. Cbx7 and Cbx8 have only ~200 targets that are not overlapping between the two proteins. These distinct Cbx7 and Cbx8 targets show reciprocal expression patterns along hematopoietic different...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-36658 | biostudies-arrayexpress
UnknownNational Assessment of Statin Therapy in Patients Hospitalized with Acute Myocardial Infarction: Insight from China PEACE-Retrospective AMI Study, 2001, 2006, 2011.
Not available
S-EPMC4825974 | biostudies-literature
UnknownST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data.
Not available
S-EPMC4415374 | biostudies-literature
UnknownTrends in early aspirin use among patients with acute myocardial infarction in China, 2001-2011: the China PEACE-Retrospective AMI study.
Not available
S-EPMC4323779 | biostudies-literature
UnknownTrends in cardiac biomarker testing in China for patients with acute myocardial infarction, 2001 to 2011: China PEACE-retrospective AMI study.
Not available
S-EPMC4404305 | biostudies-literature
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