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ProteomicsClinicopathological Observation and Initial Exploration of Characteristic Biomarkers in Apocrine Breast Carcinoma
Perform proteomic profiling comparing triple-negative apocrine carcinoma (TNAC) and luminal androgen receptor-type triple-negative breast cancer (LAR-TNBC) to elucidate their molecular distinctions and validate TNAC as a distinct entity separate from LAR-TNBC.
ORGANISM(S): Homo Sapiens 
2026-01-26 | PXD073549 |
ProteomicsDeacetylation of Septin4 by NAD-dependent deacetylase SIRT2 mitigates damaging effects of hypertensive nephropathy
RATIONALE: Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective therapeutic target has not yet been identified. The ...
ORGANISM(S): Mus Musculus 
2022-12-05 | PXD038538 |
ProteomicsMechanistic Insight into Glioma Through Spatially Multidimensional Proteomics
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we pro...
ORGANISM(S): Homo Sapiens 
2023-07-20 | PXD043970 |
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