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ProteomicsProteomic analysis of human aqueous humor from Fuchs uveitis syndrome
We performed liquid chromatography-tandem mass spectrometry-based proteomic methods to evaluate the aqueous humor protein profiles of all 37 samples.
ORGANISM(S): Homo Sapiens 
PXD043597 |
ProteomicsComprehensive proteomic profiling of aqueous humor in idiopathic uveitis and Vogt-Koyanagi-Harada syndrome
In this study, 44 AH samples were subjected to a quantitative analysis using SWATH, and 557 proteins were identified in each sample according to a well-established library of 634 proteins. Proteomic profiles in AH of IU and VKH groups were significantly different from normal controls, whereas relati...
ORGANISM(S): Homo Sapiens 
PXD041318 |
ProteomicsTargeted proteomic analysis of aqueous humor in idiopathic uveitis and Vogt-Koyanagi-Harada syndrome
Extreme gradient boosting (XGBoost), an efficient and robust machine learning algorithm, was used to develop a model for classifying the IU, VKH, and control groups. The three proteins deemed most important were transferrin (TF), calsyntenin-1 (CLSTN1), and retinol-binding protein 4 (RBP4), which re...
ORGANISM(S): Homo Sapiens 
PXD043575 |
ProteomicsTandem mass tag-based quantitative proteomic analysis reveals proteins involved in hemolytic hyperbilirubinemia-induced brain injury in rats
Hemolytic hyperbilirubinemia-induced brain injury (HHIBI) can cause neonatal death, and survivors often have neurological sequelae, including irreversible motor sensitive and cognitive abnormalities. However, the underlying mechanisms remain elusive. By identifying differentially abundant proteins (...
ORGANISM(S): Rattus Rattus 
PXD041604 |
ProteomicsProteomic landscape of plasma and plasma-derived sEVs and lEVs in uveitis and posterior scleritis
Uveitis and posterior scleritis are sight-threatening diseases with undefined pathogenesis, accurate diagnosis remains challenging. Here, two plasma-derived extracellular vesicle (EV) subpopulations, small and large EVs, were obtained from patients with uveitis and posterior scleritis and subjected ...
ORGANISM(S): Homo Sapiens 
PXD036844 |
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