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TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
TranscriptomicsPRR7 is a novel NMDA-dependent inhibitor of c-Jun ubiquitination in neurons
Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults such as stroke and epilepsy. NMDA receptor (NMDAR) antagonists block c-Jun upregulation and prevent neuronal cell death following excito...
ORGANISM(S): Rattus norvegicus 
2014-10-25 | E-GEOD-62686 | biostudies-arrayexpress
UnknownGut microbiota regulates hepatic ketogenesis and lipid accumulation in ketogenic diet-induced hyperketonemia by disrupting bile acid metabolism.
Not available
S-EPMC12026136 | biostudies-literature
MetabolomicsSymbiotic bacteria-derived organic acids protect Delia antiqua larvae from entomopathogenic fungal infection

The protection of associated microbiota for their animal hosts against pathogen infection has been studied widely over the last 100 years. However, how those microbes protect the animal host is limitedly investigated. In former studies, body surface microbes of one insect, Delia antiqua,...

2020-11-12 | MTBLS2074 | MetaboLights
UnknownPrenatal and Postnatal Ambient Air Pollution and Kawasaki Disease: A Systematic Review and Meta-Analysis.
Not available
S-EPMC11937670 | biostudies-literature
UnknownDisruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Not available
S-EPMC3511101 | biostudies-literature
TranscriptomicsMdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [HCT116 microarray]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that Mdm2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, Mdm2 depletion in ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73294 | biostudies-arrayexpress
UnknownStructural basis of AMPK regulation by adenine nucleotides and glycogen.
Not available
S-EPMC4650587 | biostudies-literature
UnknownAssociation of an IGHV3-66 gene variant with Kawasaki disease.
Not available
S-EPMC7585995 | biostudies-literature
UnknownExploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma.
Not available
S-EPMC11753693 | biostudies-literature
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