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ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063840 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [II]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063859 | Pride
Osteoarthritis Il-1β 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [III]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063864 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063537 | Pride
Palmitoylation Senescence 
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