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TranscriptomicsMLL Fusion Proteins Preferentially Regulate a Small Set of Wild Type MLL Target Genes in the Leukemic Genome
MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations encode chimeric MLL fusions that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is un...
ORGANISM(S): Mus musculus 
2011-04-28 | E-GEOD-24794 | biostudies-arrayexpress
GenomicsGenentech Colon Cancer Screen
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alte...
EGAS00001000288 | EGA
UnknownAcute Pancreatitis-Progress and Challenges: A Report on an International Symposium.
Not available
S-EPMC4890478 | biostudies-literature
ProteomicsGlycan Markers of Human Stem Cells Assigned with Beam Search Arrays
Glycan antigens recognized by monoclonal antibodies have served as stem cell markers. To understand regulation of their biosynthesis and their roles in stem cell behavior precise assignments are required. We have applied state-of-the-art glycan array technologies to compare the glycans bound by five...
ORGANISM(S): Cellular Organisms 
2019-06-18 | PXD013972 | JPOST Repository
UnknownDSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.
Not available
S-EPMC11329725 | biostudies-literature
UnknownIntegration of Germline Pharmacogenetics Into a Tumor Sequencing Program.
Not available
S-EPMC7434089 | biostudies-literature
TranscriptomicsSorted tumor RNA-seq of syngeneic murine mutant IDH1 ICC tumor model treated with IDH1 inhibitor against vehicle
IDH1 is the most commonly mutated metabolic gene across human cancers, with the highest mutational frequency observed in AML, glioma, chondrosarcoma, and intrahepatic cholangiocarcinoma. Mutations of the hot spot R132 codon alter the activity of the IDH1 enzyme, resulting in the NADPH-dependent conv...
ORGANISM(S): Mus musculus 
2021-11-23 | E-MTAB-11112 | biostudies-arrayexpress
GenomicsColon_Illumina_2.5M_Controls - samples
Colon matched tumour samples
EGAD00010000274 | EGA
GenomicsColon_Illumina_2.5M_Cases - samples
Colon tumour samples
EGAD00010000272 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:54:35:559-18 - samples
Exome capture sequencing of colon tumor/normal pairs
EGAD00001000216 | EGA
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