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GenomicsAn alternative pluripotent state confers interspecies chimaeric competency [WGBS]
In this study, we show that by simple modulation of extrinsic signaling pathways, a new class of pluripotent stem cells, referred to as region selective epiblast stem cells (rsEpiSCs), could be efficiently derived from different stages of the early embryo. rsEpiSCs share features of primed pluripote...
ORGANISM(S): Mus musculus 
2015-05-06 | E-GEOD-63568 | biostudies-arrayexpress
TranscriptomicsReprogramming by Sall4, Nanog, Esrrb and Lin28 produces high quality iPSCs with a molecular signature of developmental potency that resembles ESCs.
To reveal a gene expression signature associated with developmental competence, we selected the following groups of iPSC lines for microarray analysis. i) “Poor quality” iPSCs: This group included the three OSKM-iPSC lines Nanog-GFP OSKM#2, Oct4-GFP OSKM#2 and KH2 OSKM27, that either did not produce...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-45173 | biostudies-arrayexpress
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