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TranscriptomicsHuman BRAF-V600E melanoma cell lines drug sensitive vs drug resistant
aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline Two condition experiment: two BRAF-V600E mutant cell lines (drug sensitive - parental baseline) vs two derived sublines after chronic exposure to the MEK inhibitor trametinib (drug resista...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49430 | biostudies-arrayexpress
TranscriptomicsIntegrative genomic analysis of sporadic clear cell Renal Cell Carcinoma
Human clear cell renal cell carcinoma (ccRCC) is a common cancer of the kidney. We applied an integrated approach to identify important factors that influence carcinogenesis in ccRCC. 33 frozen ccRCC samples were subject to copy number analysis. The data was analyzed to identify factors affecting tu...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-27852 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples for HIF-alpha expression and VHL genotype, in order to define differentially expressed genes Keywords: Patient Sampl...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-11904 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples based on HIF-alpha expression, in order to examine levels of genomic DNA aberration. Keywords: Patient Sample Study ...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-13282 | biostudies-arrayexpress
TranscriptomicsArray-based Comparative Genomic Hybridization of Melanoma Cell Lines
This study explored the role of targeting protein for Xklp2 (TPX2), located with 20q11.2, in melanoma pathogenesis, based on initial findings that it was commonly gained and overexpressed. TPX2 copy number was evaluated in melanoma cell lines compared to control DNA. Thrity-three cell lines were ana...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-38946 | biostudies-arrayexpress
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