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ProteomicsDrug-driven phenotypic convergence supports rational treatment strategies of chronic infections
Chronic Pseudomonas aeruginosa infections evades antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P.aeruginosa towards clinically relevant antibiotics leads to phenotypic convergence towards distinct states. These st...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2018-10-23 | PXD007972 | Pride
Collateral sensitivity Cystic fibrosis Nfxb Chronic infections Phenotypic convergence Drug resistance Pseudomonas aeruginosa 
ProteomicsA microbial supply chain for production of anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to chemically synthesize, the world’s supply chain for vinblastine relie...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-21 | PXD025067 | Pride
Yeast synthetic biology Monoterpene indole alkaloids Natural products 
ProteomicsA microbial supply chain for production of anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to chemically synthesize, the world’s supply chain for vinblastine relie...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-09-09 | PXD024976 | panorama
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