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GenomicsRole of Prdm14 in mouse embryonic stem cells: ChIP-seq and RNA-seq analyses
Prdm14 is a PR-domain and zinc-finger protein whose expression is restricted to the pluripotent cells of an early embryo, embryonic stem cells (ESCs), and germ cells. Here we show that Prdm14 safeguards mouse ESC maintenance by preventing induction of extraembryonic endoderm (ExEn) fates. Conversely...
ORGANISM(S): Mus musculus 
2010-12-23 | E-GEOD-25409 | biostudies-arrayexpress
GenomicsJarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
We report on mechanism of interaction between PRC2 complex and Jarid2 and their role in pluripotent cells Examination of PRC2 genomic localization by analysis of Jarid2, Ezh2, Suz12 and Jarid1a occupancy
ORGANISM(S): Mus musculus 
2009-12-24 | E-GEOD-18776 | biostudies-arrayexpress
GenomicsA unique chromatin signature uncovers early developmental enhancers in humans
Cell fate transitions involve integration of genomic information encoded by regulatory elements, such as enhancers, with the cellular environment. However, identification of the genomic sequences that control the earliest steps of human embryonic development represents a formidable challenge. Here w...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-24447 | biostudies-arrayexpress
GenomicsEnhancer divergence and cis-regulatory evolution in the human and chimpanzee neural crest
Here we derive human and chimpanzee cranial neural crest cells (CNCCs) and profile histone modifications, transcription factors, chromatin accessibility and gene expression to systematically and quantitatively annotate evolutionary divergence of craniofacial cis-regulatory landscapes. Histone modifi...
ORGANISM(S): Homo sapiens 
2015-09-11 | E-GEOD-70751 | biostudies-arrayexpress
GenomicsETO Family Protein Mtgr1 Mediates Prdm14 Functions in Stem Cell Maintenance
Prdm14 is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation. It exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation. Here, we show that this rep...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-74547 | biostudies-arrayexpress
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