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ProteomicsSegmental X-chromosome monosomies are compensated by transcriptional upregulation.
XX mice undergo both X-chromosome inactivation (XCI) and X-chromosome upregulation (XCU) to balance X-linked gene dosage with autosomes and XY mice. XCU has also been reported in XY cells, as well as cells with a single copy of the X-chromosome (XO). The two dosage compensation processes have been s...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-19 | PXD057399 | Pride
X-chromosome upregulation (xcu) Transcription X-chromosome X-chromosome inactivation (xci) 
TranscriptomicsSingle-cell RNA sequencing of differentiating mESCs using Smart-seq3
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were adapted to 2i/LIF and female cells grown in serum/LIF conditions were differentiated using Fgf2 and Activin...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-9324 | biostudies-arrayexpress
TranscriptomicsMulti-modal single-cell sequencing of differentiating mESCs using Smart-seq3 and scATAC-seq
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were grown in serum/LIF conditions were differentiated using Fgf2 and Activin A for 1, 2, 4 and 7 days to induce...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-10714 | biostudies-arrayexpress
TranscriptomicsX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [scRNA-seq]
Gene dosage compensation mechanisms are crucial for mammalian development. In mice, recent findings show that cells can sense the number of X chromosomes. Loss or inactivation of one of the two X chromosomes is compensated by upregulating the remaining active X chromosome, a process termed X-chromos...
ORGANISM(S): Mus musculus 
2025-06-19 | GSE282790 | GEO
GenomicsX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [ChIP-seq]
Gene dosage compensation mechanisms are crucial for mammalian development. In mice, recent findings show that cells can sense the number of X chromosomes. Loss or inactivation of one of the two X chromosomes is compensated by upregulating the remaining active X chromosome, a process termed X-chromos...
ORGANISM(S): Mus musculus 
2025-06-19 | GSE282785 | GEO
TranscriptomicsX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [RNA-seq]
Gene dosage compensation mechanisms are crucial for mammalian development. In mice, recent findings show that cells can sense the number of X chromosomes. Loss or inactivation of one of the two X chromosomes is compensated by upregulating the remaining active X chromosome, a process termed X-chromos...
ORGANISM(S): Mus musculus 
2025-06-19 | GSE282784 | GEO
GenomicsX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [RNA-seq]
X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [RNA-seq]
PRJNA1190421 | ENA
GenomicsX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [ChIP-seq]
X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [ChIP-seq]
PRJNA1190422 | ENA
GenomicsX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [scRNA-seq]
X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels [scRNA-seq]
PRJNA1190423 | ENA
UnknownX-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels.
Not available
S-EPMC12484829 | biostudies-literature
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