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MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
TranscriptomicsCharacterization of protoporphytin IX effects on X-ray irradiation in Hela cells in vitro
Hela cells were used to evaluate the protoporphytin IX (PpIX) effects on X-ray irradiation. Treatment conditions were (1) control group (untreated cells); (2) cells treated with 1 μg /ml PpIX for 6 hours; (3) cells irradiated with 3Gy X-rays; (4) cells treated with 1 μg /ml PpIX for 6 hours prior ...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-61805 | biostudies-arrayexpress
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells
MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular res...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30132 | biostudies-arrayexpress
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells [miRNA data]
MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular res...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30130 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human fibroblasts exposed to X-ray radiation
This dataset is composed by the transcriptomic, proteomic and phosphoproteomic profile of primary human fibroblasts exposed to two different doses of radiation: an acute X-ray radiation dose, and an accumulative X-ray radiation dose. These data were employed to apply and evaluate different computati...
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-10456 | biostudies-arrayexpress
TranscriptomicsExpression data from human unbilical endothelial cells (HUVEC) irradiated with X-ray
To understand the molecular mechanism underlying inflammatory reaction in vascular system post exposure to ionizing radiation, we carried out microarray analysis in HUVEC exposed with X-ray HUVEC were irradiated with X-ray (2.5 Gy) and then cultured for 6, 12, and 24 hr. Total RNA were extracted fro...
ORGANISM(S): Homo sapiens 
2016-01-21 | E-GEOD-76484 | biostudies-arrayexpress
TranscriptomicsFe ions and X-ray radiation exposure of Est2-immortalised human coronary artery endothelial cells - 1 day and 7 days post-irradiation
In recent years there is a growing epidemiological indication of excess risk of cardiovascular disease at low doses of ionizing radiation without a clear-cut threshold. It is proposed that damage to the vascular endothelium is critical in radiation-related cardiovascular diseases. In order to identi...
ORGANISM(S): Homo sapiens 
2017-10-02 | E-MTAB-5754 | biostudies-arrayexpress
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells [mRNA data]
'MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular re...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30131 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila x-ray sensitive and resistant embryos after exposure to x-rays
stage 9-11 embryos are sensitive to x-ray induced cell death, while stage 13-15 embryos are highly resistant. The gene expression changes induced by x-ray in sensitve vs resistant embryos appear to be qualitatively different.
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-1005 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Solanum tuberosum tubers growing at different velocities
X-ray CT was used to determine the growth velocity of individual tubers. RNA was extracted from tubers growing at different velocities and used for microarray hybridisation.
ORGANISM(S): Solanum tuberosum 
2010-02-08 | E-MEXP-2484 | biostudies-arrayexpress
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