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TranscriptomicsSingle Cell RNA-sequencing of Pancreatic Circulating Tumor Cells
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RN...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-51372 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of circulating tumour cells implicates WNT signaling in pancreatic cancer metastasis (mouse data)
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. While these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne dissemination of cancer. Here, we adapted a microfluidic d...
ORGANISM(S): Mus musculus 
2012-08-17 | E-GEOD-40171 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of circulating tumour cells implicates WNT signaling in pancreatic cancer metastasis (human data)
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. While these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne dissemination of cancer. Here, we adapted a microfluidic d...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-40174 | biostudies-arrayexpress
TranscriptomicsHuman Pancreatic CTCs Express the ECM Protein SPARC
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To determine the relevance of ECM protein expression to human disease, CTCs were isolated from the blood of metastatic PDAC patients and subjected to singl...
ORGANISM(S): Homo sapiens 
2014-09-22 | E-GEOD-60407 | biostudies-arrayexpress
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