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TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primarylung cancer tumors and their SCID mouse xenografts
MicroRNA expression in eight human non-small cell lung carcinoma xenografts grown in SCID mice was compared with the primary human tumors. Formalin-fixed and paraffin-embedded tissue specimens were used.
ORGANISM(S): Homo sapiens 
2009-06-30 | E-TABM-720 | biostudies-arrayexpress
TranscriptomicsEffects of SGI-110 on A2780 ovarian cancer xenografts
Genome-wide DNA methylation profiles of SGI-110-treated ovarian cancer xenografts were obtained using next generation Illumina Infinium 450k assay which includes over 450,000 GpG sites. DNA from 6 samples were hybridized to the Illumina's Infinium HumanMethylation 450 BeadChip
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-55613 | biostudies-arrayexpress
TranscriptomicsSNP profiling of pancreatic adenocarcinoma (PDAC) xenografts
Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. Patient-derived xenografts (PDX) are appearing as a prime approach for preclinical studies despite being insufficiently characterized as a model of the human disease and its diversity. We genera...
ORGANISM(S): Homo sapiens 
2017-12-12 | E-MTAB-5006 | biostudies-arrayexpress
TranscriptomicsA Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenografts
Translational breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. In an effort to overcome these limitations, we propagated a cohort of human breast tumo...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-34412 | biostudies-arrayexpress
TranscriptomicsRNASeq profiling of AZD8186-treated HCC70 xenografts
HCC70 xenografts treated with 11 doses of AZD8186 (100mg/kg BID) were compared to DMSO-treated control xenografts
ORGANISM(S): Homo sapiens 
2017-11-01 | E-MTAB-4656 | biostudies-arrayexpress
TranscriptomicsExpression Profiling and Array Comparative Genomic Hybridization of Pancreatic Xenografts and Cell Lines
This SuperSeries is composed of the following subset Series: GSE25273: Array Comparative Genomic Hybridization of Pancreatic Xenografts and Cell Lines GSE26088: Expression Profiling of Pancreatic Xenografts and Cell Lines Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-12-15 | E-GEOD-26089 | biostudies-arrayexpress
TranscriptomicsGSK3B shRNA in Panc-1 xenografts
The Panc-1 human pancreatic cancer line (ATCC) was constructed to stably express control or GSK3B shRNA. Control or GSK3B shRNA expressing Panc-1 cells were implanted subcutaneously into the flanks of 3-5 week old, female, athymic nude mice. Tumors were grown to at least 250mm3. Tumor tissue was mic...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-35351 | biostudies-arrayexpress
ProteomicsPhosphoproteome analysis of pediatric acute leukemia patients and matched xenografts
Proteomics reveal PTM stability after xenotransplantation in murine models. Phosphopeptides enriched using magnetic FeNTA beads were analyzed by Data Independent Acquisition (DIA) mass spectrometry. High-pH fractionation was performed on a pool of samples, followed by data dependent acquisition (DDA...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-02 | MSV000084645 | MassIVE
TranscriptomicsCopy number variation comparison between control and CC214-2 resistant GBM39 xenografts
Here we present genome-wide copy number variation data on two vehicle treated and two CC214-2 (an mTOR kinase inhibitor) resistant GlioBlastoma Multiforme 39 (GBM39) xenografts, showing the absence of significant differences between the two groups, demonstrating that resistance to CC214-2 is due to ...
ORGANISM(S): Homo sapiens 
2013-12-06 | E-GEOD-53042 | biostudies-arrayexpress
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