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TranscriptomicsGene Expression in induced Treg cell from CD4+ Naive T cell isolated from miR-31fl/fl/CD4Cre vs Control mice
A microarray study performed in iTreg of miR-31fl/fl/CD4Cre and control mice to identify genes that are regulated by the miR-31. CD4+ naM-CM-/ve T cells from miR-31fl/fl mice and miR-31fl/flCD4Cre mice were used to induce iTreg in vitro. Four independent experiments were performed. MiR-31fl/fl/CD4Cr...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61938 | biostudies-arrayexpress
TranscriptomicsHuman bone-derived mesenchymal stem cells: SLE patients vs normal controls
Previous studies showed that bone marrow derived-mesenchymal stem cells (BMMSCs) from patients with systemic lupus erythematosus (SLE) and lupus animal models have deficiency in their capacities of proliferation, differentiation, secretion of cytokines and other functions. In this study, we aim to i...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-21649 | biostudies-arrayexpress
GenomicsRisk Variants for Exfoliation Syndrome Modulate Antisense Promoter Activity Within the LOXL1 Locus
The goal of this study was to identify functional variants that play a role in exfoliation syndrome (XFS) pathogenesis. We sequenced the entire LOXL1 locus in 50 South African XFS cases and 50 matched controls. The most strongly associated variants in this dataset were found in a ~7kb region spannin...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-66877 | biostudies-arrayexpress
TranscriptomicsA dynamic H3K27ac signature defines VEGF-regulated endothelial enhancers
Histone modifications are now well-established regulators of transcriptional programs that distinguish distinct cell states. However, the kinetics of histone modification and their role in mediating rapid, signal-responsive changes in gene expression have been little studied on a genome-wide scale. ...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-41166 | biostudies-arrayexpress
TranscriptomicsEts homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [DNAse-seq]
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF c...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-63399 | biostudies-arrayexpress
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