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ProteomicsHuman diffuse intrinsic pontine glioma (DIPG) LC-MSMS
Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoting malign...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD053094 | Pride
Human Dipg cell lines Ip-ms 
ProteomicsHuman diffuse intrinsic pontine glioma (DIPG) LC-MSMS
Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoting malign...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD060271 | Pride
Human Dipg cell lines Ip-ms 
ProteomicsLncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
LC-MS/MS combined with the ChIRP for the mESCs of WT and lncRNA-Smad7 KO
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD036394 | Pride
Mouse lc-ms/ms mescs chirp 
TranscriptomicsSmad4 and Trim33 dependend nodal/activin responsive genes in differentiated mouse ESCs
In differentiated mouse ESCs, most of the nodal/activin responsive genes are dependent on both Smad4 and Trim33, some are solely dependent on Smad4, and some are dependent on Trim33. Ebs at Day2.5 from WT, Smad4 null, and Trim33 knock-down ESCs, were treated with activin or SB 431542 for 2 h.
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-32903 | biostudies-arrayexpress
ProteomicsThe proteomic navigator of human aging
Proteins are the cornerstone of human life, yet the proteomic landscape of aging across human tissues remains largely unexplored. Here, we present a comprehensive proteomic analysis of 520 samples from 15 human tissues, spanning a 50-year lifespan. Our study compiles a proteomic encyclopedia of mult...
ORGANISM(S): Homo Sapiens 
2024-12-06 | PXD058638 |
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