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TranscriptomicsCryptic Transcription in a set2∆ in Saccharomyces cerevisiae
In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-17 | E-GEOD-13310 | biostudies-arrayexpress
GenomicsH2A.X native ChIP-Seq in ESC and iPSC: Histone Variant H2A.X Mediated Epigenetic Mechanisms are Critical for Maintaining Genome Stability and Pluripotency in ES and iPS Cells
It is well-known that embryonic stem cells (ESC) are much more sensitive to replication-induced stress than differentiated cells but the underpinning mechanisms are largely unknown. H2A.X, a minor variant of H2A, constitutes only 1-10% of the mammalian genome. H2A.X plays a well-known for role in t...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42306 | biostudies-arrayexpress
TranscriptomicsIdentification of a stable molecular signature in breast tumor endothelial cells that persists ex vivo
Long-term, in vitro propagation of tumor-specific endothelial cells (TEC) allows for ex vivo functional studies and gene expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically-engineered mouse model (GEMM) of mammary adenocarcinoma (C3-TAg), we have optimize...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-50555 | biostudies-arrayexpress
GenomicsH2A.X native ChIP-Seq in TSC; Histone Variant H2A.X Mediated Epigenetic Mechanisms are Critical for Pluripotency in ES and iPS Cells
With the advent of the induced pluripotent stem cell (iPSC) technology, how to distinguish the developmental potentials of the iPSC clones with molecular approaches becomes an imperative issue. Herein, we demonstrated that histone variant H2A.X plays an unexpected role in distinguishing the develop...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-57216 | biostudies-arrayexpress
TranscriptomicsHistone Variant H2A.X Plays Novel Roles in Cell Lineage Commitment and Genomic Stability in ESC and iPSC
Herein, we demonstrated that the cell lineage commitment is unexpectedly regulated by the novel functions of H2A.X, a histone variant which was only well-known for its role in genome integrity maintenance previously. Surprisingly, only in ESCs but not differentiated cells, H2A.X is specifically targ...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-49147 | biostudies-arrayexpress
GenomicsConversion of Fibroblasts into Functional Trophoblast Stem-like Cells
Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-70234 | biostudies-arrayexpress
TranscriptomicsCNV analysis of iPS cell lines and H2A.X knockout ES cell
It is well-known that embryonic stem cells (ESC) are much more sensitive to replication-induced stress than differentiated cells but the underpinning mechanisms are largely unknown. H2A.X, a minor variant of H2A, constitutes only 1-10% of the mammalian genome. H2A.X plays a well-known for role in t...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42266 | biostudies-arrayexpress
GenomicsMus musculus
Conversion of Fibroblasts into Functional Trophoblast Stem-like Cells
PRJNA288028 | ENA
GenomicsMus musculus
H2A.X SMRT-ChIP
PRJNA292545 | ENA
GenomicsMus musculus
RNASeq in mouse Alkbh1 KO and WT ESC
PRJNA292542 | ENA
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